Flashcards in Pathogens and the host Deck (48)
bacteria capable of causing disease.
signs and symptoms of clinical infection
-increased white cell count
-increased C reactive protein (CRP)
heart rate that exceeds the normal resting rate.
sudden feeling of cold, increased temperature, sweating and shivering
organism that can cause disease.
organism which is part of the normal body flora.
requirements for pathogenicity
ability to become established
ability to cause harmful effects once established
methods to increase infectivity
-evasion of immune system
invasiveness example: streptococcus pyogenes
-connective tissue breakdown
types of toxins produced by pathogens
released extracellularly by the micro-organism.
act on the GI tract
structurally part of the gram negative cell wall
caused by clostridium tetani, exotoxin released acts on nerve synapse and causes the inhibition of inhibitory neurotransmitter release.
debridement (removal of dead/infected tissue), antibiotics and antitoxin
causes by vibrio cholerae, colonises small intestine produces an enterotoxin which causes increase in cAMP levels, increases ion conc in small intestine which causes dehydration.
treatment of cholera
certain exotoxins of strep pyogenes and Staph aureus stimulate the division of T-cells in the absence of specific antigen. overwhelming cytokine production causes toxic shock
caused by E. coli and other gram negative bacilli. induces uncontrolled host response, cytokine production, fevers, rigors hypotension, tachycardia, collapse
the establishment of the pathogen at the appropriate portal of entry
after the primary infection the virus lies dormant in host cells, viral DNA and RNA in host cells which is not expressed in large quantities.
infected host is a carrier for the disease but does not show any symptoms.
the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce
non-specific immunity formed of skin, gastric acid. muco-ciliary escalator and phagocytic cells
-polymorphs eg. neutrophils, eosinophils, basophils (fight acute infection
-macrophages (fight chronic infection)