Drugs that Affect Bone and Mineral Homeostasis Flashcards Preview

Pharmacology > Drugs that Affect Bone and Mineral Homeostasis > Flashcards

Flashcards in Drugs that Affect Bone and Mineral Homeostasis Deck (15)
1

High dose PTH causes?

Increased bone resorption, hypercalcemia, and hyperphosphatemia

2

Low intermittent doses of PTH causes?

Net increase in bone formation

3

Signs and symptoms of excess PTH

Painful bones
Renal stones
Abdominal groans
Psychiatric overtones

4

Used in rickets and osteomalacia

Ergocalciferol
Cholecalciferol

5

Used in secondary hyperparathyroidism in CKD to lower serum PTH

Calcitriol (AE: causes hypercalcemia)

Paricalcitol: rarely precipitates hypercalcemia

Cinacalcet: suppresses PTH synthesis and release

6

Used in psoriasis

Calcipotriene

7

First line drug for Paget's disease of bone

Calcitonin
Alendronate (Bisphosphonate)

Pamidronate- most useful for the treatment of hypercalcemia in Paget's disease

8

Used in hyperphosphatemia in CKD hypoparathyroidism, and Vitamin D intoxication

Sevelamer
(phosphate binding resin)

9

Recombinant PTH used for the treatment of osteoporosis; acts through PTH receptors to produce a net increase in bone formation

Teriparatide

10

MOA of denosumab

Binds to RANKL and prevents it from stimulating osteoclast differentiation and function

11

Used for hyperparathyroidism

Cinacalcet (Calcimimetic)- activates the calcium-sensing receptor

12

Routinely added to calcium supplements and milk for the purpose of preventing rickets in children and osteomalacia in adults

Cholecalciferol

13

Long term use of this drug causes osteoporosis

Glucocorticoids

14

MOA of bisphosphonates (eg. alendronate)

Suppresses the activity of osteoclasts and inhibits bone resorption

15

Used for osteoporosis in postmenopausal women

Raloxifene (estrogen agonist effect in bones)