Lab Exam 1 Notes Contd Flashcards
(124 cards)
the contraction of skeletal and cardiac muscle fibers can be considered in terms of 3 events – … of the muscle cell, …., and shortening of the muscle cell due to … within it
electrical excitation; excitation contraction coupling; sliding of the myofilaments
because the plasma membrane is more permeable to … than to …, the cell’s resting membrane potential is more negative inside than outside
K+; Na+
the resting membrane potential is of particular interest in excitable cells, like muscle cells and neurons, because changes in that voltage underlie their ability to … (to … and/or …)
do work; contract; issue electrical signals
when a muscle cell is stimulated, the sarcolemma becomes temporarily more permeable to sodium ions, which enters the cell. this sudden influx of sodium ions alters the membrane potential, such that the cell interior becomes less negatively charged – ….
depolarization
when depolarization reaches a certain level and the sarcolemma momentarily changes its polarity, a depolarization wave travels along the sarcolemma. even as the influx of sodium occurs, the sarcolemma becomes becomes less permeable to sodium and more permeable to potassium, which moves out of the cell –
repolarization
the … is the period of time when sodium permeability of the sarcolemma is rapidly changing and maximal, and the following period when sodium permeability becomes restricted. during this period there is no possibility of generating another action potential
absolute refractory period
as sodium permeability is gradually restored to resting levels during repolarization, an especially strong stimulus to the muscle cell may provoke another action potential –> …
repolarization restores the muscle cell’s normal excitability
relative refractory period
if the muscle cell is stimulated to contract rapidly repeatedly, the changes in sodium and potassium concs near the membrane begin to reduce its ability to respond. the … must become more active to reestablish the ionic concs of the resting state
sodium-potassium pump
Propagation of the action potential along the sarcolemma causes the release of …. from storage in the … within the muscle cell.
calcium ions (Ca2+); sarcoplasmic reticulum;
When the calcium ions bind to the regulatory protein… on the actin myofilaments, they act as an ionic trigger that initiates …, and the actin and myosin filaments slide past each other. Once the action potential ends, the calcium ions are almost immediately transported back into the sarcoplasmic reticulum. Instantly the muscle cell relaxes.
troponin; contraction;
Muscle cell contraction is initiated by generation and transmission of an …along the sarcolemma. This electrical event is coupled to the sliding of the …—contraction—by the release of calcium ions (Ca2+).
action potential ; myofilaments;
generally there is … with ATP alone. There is … with the salt solutions alone. … occurs in the presence of ATP and the proper concs of potassium and magnesium ions
little or no contraction; no contraction; maximum contraction
a single contraction of skeletal muscle is called a …
a tracing of this shows three distinct phases: latent, contraction, and relaxation
muscle twitch
the … is the interval from stimulus application until the muscle begins to shorten. although no activity is indicated on the tracing during this phase, … is occurring within the muscle
latent period; excitation-contraction coupling;
during the …, the muscle fibers shorten; the tracing shows an increasingly higher needle deflection and the tracing peaks
period of contraction
during the .., represented by a downward curve of the tracing, the muscle fibers relax and lengthen
period of relaxation
If a muscle is stimulated with a rapid series of stimuli of the same intensity before it has had a chance to relax completely, the response to the second and subsequent stimuli will be greater than to the first stimulus. This phenomenon, called …, or …, occurs because the muscle is already in a … state when subsequent stimuli are delivered.
wave summation; temporal summation; partially contracted;
voltage that produces the maximal strength of contraction, and is the weakest stimulus at which all muscle cells are being stimulated: …
maximal stimulus
Stimulation of a muscle at an even higher frequency will produce a “fusion” (complete tetanization) of the summated twitches. In effect, a single sustained contraction is achieved in which no evidence of relaxation can be seen. …, or …, demonstrates the … generated by a skeletal muscle
Fused tetanus; complete tetanus; maximum force
… is a reversible physiological condition in which a muscle is unable to contract even thought it is being stimulated. it can occur with short-duration maximal contraction or long-duration submaximal contraction
muscle fatigue
several factors contribute to muscle fatigue, most of which affect …
one theory involves the buildup of … from ATP and creatine phosphate breakdown, which may block …
another theory suggests that … in the T tubules may block ca release from the SR and alter the membrane potential of the muscle fiber
excitation-contraction coupling; Pi; calcium release from the SR; potassium accumulation
When the fibers of a skeletal muscle are slightly stretched by a weight or tension, the muscle responds by …and thus is capable of doing more work. When the actin and myosin barely overlap, sliding can occur along nearly the entire length of the actin filaments. If the load is increased beyond the optimum, the latent period becomes longer, contractile force decreases, and… (fatigue) occurs more quickly. With excessive stretching, the muscle is unable to develop any active tension and no contraction occurs. Since the filaments no longer overlap at all with this degree of stretching, the sliding force cannot be generated.
contracting more forcibly; relaxation;
A single skeletal muscle consists of numerous elongated skeletal muscle cells, also called skeletal muscle …. These muscle cells are excited by motor neurons of the central nervous system whose axons terminate at the muscle. an axon of a motor neuron branches profusely at the muscle. each branch produces multiple …, each of which innervates a single fiber
fibers; axon terminals
the most important organizational concept in the physiology of muscle contraction is the …, a single motor neuron and all of the cells within a muscle that it activates
motor unit