Section 6 Growth and Development Flashcards Preview

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Flashcards in Section 6 Growth and Development Deck (31):
1

Adrenal indufficieny:

no feedback to prevent the formation of ACTH, leads to stimulation of MSH

2

What cells release growth hormone?

anterior pituitary gland, somatotrophs

3

Somatomedins:

other factors responsible for linear growth, stimulate there compound to be released (bone differentiation formation, etc.)

4

Insulin and IGF's are examples of:

Somatomedins

5

Insulin like growth factors:

IgF-1, IGF-2, etc

6

major Insulin like growth factors:

IgF-1,

7

I Gf-1 release from liver leads to:

the production of insulin like growth factors

8

What are directly involved in bone tissues, organ growth, etc?

insulin like growth factors igf1 is the major one

9

Metabolic effect of growth hormone:

increases blood glucose

10

Anterior pituitary gland response to low carbohydrates in body:

somatostatin inhibits and suppresses growth hormone release OR positively regulate GNRH

11

High carbs work through what limb?

somatostatin limb of growth hormone

12

True or False? High proteins meals inhibit growth hormone release.

F. stimulates

13

Effects of thyroxine, testosterones, and estradiol on growth hormone:

stimulatory (estrogen can inhibit bone growth by facilitating bone closure, fuse at the epiphyseal plates, premature closure)

14

True or False? There is a circadian rhythm to growth hormone.

T. nocturnal pulse, pulse doesn't change, but the amplitudes and length of pulse changes throughout life

15

Major lipolytic hormone:

growth hormone (chews up fat from marshmallow kid to a leaner body)

16

Effect of growth hormone on IGF1:

sensitizes peripheral tissues to IGF1q

17

Problem with growth hormone use:

increases greater glucose use and insulin inhibition, can lead to diabetes

18

How can a person become diabetic?

wipe out beta cells

19

True or False? Any steady increase in blood glucose levels will lead to the inhibition of the action of insulin.

T (check)

20

True or False? Thyroid hormone is a steroid.

F. steroid-like

21

Tumors can release this in the anterior pituitary gland:

growth hormone

22

True or False? Adenomas of the anterior pituitary gland are frequent.

T. (20-25%), benign

23

excess of growth hormone leads to:

eccentuation of linear growth, increase in acrol structures

24

Prepuberty:

still have the ability to grow linearly

25

Different types of retarded growth:

excess of cortisol, nutritional, thyroxine deficit, precocious puberty, dwarfism (growth hormone insensitive (Laron Dwarfism) vs. responsive

26

Effect of high ?

ca-P transport utake inhibition in Gastrointestinal, net negative balance in blood, constantly excreting in urine, leach ca and p from bone. If actively growing

27

True or False? Steroids can contribute to a person getting osteoporosis.

T

28

Ca/P level inbalance can lead to:

arrhythmia, bone resorption to maintain blood levels, intense pain during resorption

29

growth hormone responsive dwarfism:

suppress growth hormone, suppress somatotrophs, can be kicked back into the growth cycle before puberty

30

growth hormone insensitive dwarfism

peripheral insensitivity, lack of receptors, primarily in liver tissues, where insulin like growth factor arise (responsible for linear growth) no peripheral distal receptors

31

Peripheral insensitivity to growth hormone:

Laron Dwarfism