test #42 4.30 Flashcards Preview

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Flashcards in test #42 4.30 Deck (141)
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1

gross cirrhotic liver

diffuse hepatic fibrosis w/ regenerative nodules

2

granulomatous destruction of bile ducts w/ lymphocytic infiltrate

primary biliary cirrhosis

3

onion-skin bile duct fibrosis

primary sclerosing cholangitis

4

glossopharyngeal n fxn

1. somatic motor: stylopharngeus only
2. parasympathetic: otic ganglion: parotid gland
3. general sensation:
-inner surface of tympanic membrane
- eustachian tube
- posterior 1/3 of tongue
- tonsilar region
- upper pharynx (afferent gag)
- carotid body
- carotid sinus
3. visceral sensation:
taste posterior 1/3 of tongue

5

describe path of parotid gland innervation

inferior salivatory nucleus
CN IX
otic ganglion
travel along auriculotemporal n (CN V)
parotid gland

6

salivation from submandibular & sublingual gland from? parotid?

submandibular & sublingual
FACIAL
- superior salivatory nucleus, CN VII (facial) via chorda tympani n (lingual n) across submandibular ganglion

parotid:
GLOSSOPHARYNGEAL
- inferior salivaatory nucleus, CN IX (glossopharyngeal), otic ganglion, travel w/ auricotemporal n CN V

think: facial n travels THOUGH parotid, but doesn't innervate it!

7

M3 AML chromosomal translocation

t(15,17)
peroxidase +

8

M2 AML chromosomal translocation

AML w/ maturation
Aur rods present, peroxidase +

t (8,21)

9

molecular defect in CLL

deletion of 13q

10

FSH, LH, estradiol in pt w/ severe anorexia

ALL down. inadequate hypothalamic-pituitary gonadotropic secretion

11

distal ileum winding around a thin vascular stalk

think appel peel atresia

12

causes of jejunal, ileal, colonic atresia

NOT abnormal fetal development / malformations.

result from VASCULAR ACCIDENTS in utero

13

describe jejunal, ileas, colonic atresia process

vascular occlusion, diminished intestinal perfusion leads to ischemia of a segment of bowel.

subsequent narrowing / obliteration of lumen.

ileum most often affected

if SMA affect --> intestinal wall necrosis forms blind-ending proximal jejunum. terminal ileum distal to atresia forms a spiral configuration around an ileocolic vessel -- "apple peel' or 'christmas tree' deformity

14

mechanism of duodenal atresia

failure of recanalization

(for jejunal, ileal, colon --> vascular accident)

15

what favors non-renal clearance (hepatic metabolism / clearance)

high lipophilicity & high volume of distribution

lipophilic -- lets it enter hepatocyte

-- poorly eliminated in kidney as they rapidly cross tubular cell membranes after filtration

16

primary site of drug excretion

kidney

17

primary site of drug biotransformation / metabolism

liver (also does some excretion in bile)

18

calcium chelator that prevents stone formation

citrate

19

ulcer on lesser curvature of stomach can penetrate what artery

left gastric

20

ulcer on duodenum can penetrate what artery

gastroduodenal

21

where do gastric ulcers most commonly form

lesser curvature of stomach

transitional zone between acid-secreting epitheium of corpus & gastrin-producing epithlium of antrum

22

measure of fetal lung maturity

lecithin/sphingomyelin ratio
(L/S ratio)

phosphatidylcholine / sphingomyelin ratio

1/1 until 3rd trimeter.
week 25 ~ 2:1 ratio

23

phosphatidylcholine is also know as

lecithin

24

how do tyramine foods trigger hypertensive crisis w/ MAOi?

tyramine is a sympathomimetic, usu metabolized in GI tract.

MAO inhibitors block degradation, allow it to flow in circulation

25

phenelzine

MAOi

26

tyramine containing foods

cheese, sausage, wine

27

trancypromine

MAOi

28

isocarboxazid

MAOi

29

paroxetine

SSRI

30

chlomipramine

TCA