Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Anti-Arrhythmic Drugs > Flashcards

Anti-Arrhythmic Drugs Flashcards

1
Q

Sodium Channel Blockers

Class IA - PROLONGS AP duration

A

Quarter Pounder Delight

Quinidine
Procainamide
Disopyramide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Sodium Channel Blockers

Class IB - REDUCES AP duration

A

Lettuce, Mayo, Tomato, Pickles

Lidocaine
Mexiletine - for neuropathic
Tocainide
Phenytoin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Drugs that can cause AGRANULOCYTOSIS

A

CCCAPPIT Me!

Clozapine
Co-trimoxazole
Colchicine
Aminopyrine
Phenylbutazone
PTU
Indomethacin
Tocainide
Methimazole
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Sodium Channel Blockers

Class IC - NO EFFECT ON AP duration

MOST ARRHYTHMOGENIC AMONG CLASS I

A

More Extra Fries Please

Morticizine
Encainide
Flecainide
Propafenone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Nonselective Beta Blockers

A

Propanolol

Timolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Beta 1 selective beta blockers

A 
Acebutolol
Betaxolol
Esmolol
Atenolol
Metoprolol
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Partial Agonist Beta Blockers

A

Pindolol

Acebutolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Lacking local anesthetic effect BB

A

Timolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Low lipid solubility BB

A

Atenolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Shortest acting BB

A

Esmolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Longest acting BB

A

Nadolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Combined a and B blockade

A

Carvedilol

Labetalol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Class 3 - blocks K channel

PROLONGS AP duration

A

AIDS

Amiodarone
Ibutilide
Dofetilide
Dronedarone
Sotalol

Vernakalant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Amiodarone Toxicity

A 
Pulmonary fibrosis
Paresthesia
Tremors
Thyroid dysfunction
Corneal deposits
Skin deposits
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Prolongs AP duration

Prolongs:
PR interval
QRS duration
QT interval

A

IA - Procainamide, Quinidine, Disopyramide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Shortens AP duration

No effect on normal cells

A

IB - Lidocaine

17
Q

No effect on AP duration

Prolongs QRS duration

A

IC - Flecainide, Propafenone, Encanide, Moricizine

18
Q

No effect on AP duration

Prolongs PR interval

A

Class 2 - Propanolol

19
Q

Prolongs AP durations

Prolongs QT interval

A

Class III - Amiodarone, Ibutilide, Droneodarone, Sotalol

20
Q

No effect on AP duration

Prolongs PR interval

A

Class IV - Verapamil

21
Q

Adverse Effects Class Ia

A

Procainamide - SLE
Quinidine - Cinchonism
Disopyramide - Torsades des Pointes

22
Q

Adverse Effects Class II

A

HYPOglycemia
COPD exacerbation
impotence

23
Q

Adverse Effects Class III

A

Torsades de Pointes
thyroid
liver
pulmonary

24
Q

Adverse Effects Class IV

A

edema

constipation

25
Q

Why are DIHYDROPRIDINE CCBs NOT useful as antiarrhythmics

A

DIHYDROPRIDINE CCBs - evoke compensatory sympathetic discharge which facilitates arrhythmias rather than terminating them

can cause REFLEX TACHYCARDIA and PRO-ARRHYTHMOGENIC

26
Q

MOA of ADENOSINE

A

Increase in diastolic Ik of AV node that causes marked hyperpolarization and conduction block

27
Q

Adverse Effects of Adenosine

A

Flushing
Hypotension
Transient chest pain
Dyspnea

28
Q

DOC for Supraventricular Tachycardia (SVT)

A

ADENOSINE

Verapamil

29
Q

DOC for Ventricular Tachycardia (VT)

A

AMIODARONE

30
Q

DOC for Atrial Fibrillation (aFib)

A

AMIODARONE

Propafenone

31
Q

A 76-year-old retired postal worker with
rheumatoid arthritis and chronic heart disease presents with ancardiac arrhythmia and is being considered for treatment with procainamide. She is already receiving an ACE inhibitor, digoxin, and hydrochlorothiazide for her cardiac condition.

  1. In deciding on a treatment regimen with procainamide for this patient, which of the following statements is most correct?

(A) A probable drug interaction with digoxin suggests that digoxin blood levels should be obtained before and after starting procainamide.
(B) Hyperkalemia should be avoided to reduce the likelihood of procainamide toxicity.
(C) Procainamide cannot be used if the patient has asthma because it has a β-blocking effect.
(D) Procainamide cannot be used if the patient has angina
because it has a β-agonist effect.
(E) Procainamide is not active by the oral route

A

(B) Hyperkalemia should be avoided to reduce the likelihood of procainamide toxicity.

32
Q

A 76-year-old retired postal worker with
rheumatoid arthritis and chronic heart disease presents with a cardiac arrhythmia and is being considered for treatment with procainamide. She is already receiving an ACE inhibitor, digoxin, and hydrochlorothiazide for her cardiac condition

If this patient should take an overdose and manifest severe acute procainamide toxicity with markedly prolonged QRS, which of the following should be given immediately?

(A) A calcium chelator such as EDTA
(B) Adenosine
(C) Nitroprusside
(D) Potassium chloride
(E) Sodium lactate
A

(E) Sodium lactate

33
Q

A 54-year-old airline pilot is admitted to the emergency department with chest pain and a rapid heart rhythm. The ECG shows an inferior myocardial infarction and ventricular tachycardia. Amiodarone is ordered. Amiodarone

(A) Decreases PR interval in normal sinus rhythm
(B) Increases action potential duration
(C) Increases contractility
(D) Often causes liver function abnormalities
(E) Reduces resting potential

A

(B) Increases action potential duration

34
Q

. A 36-year-old woman with a history of poorly controlled thyrotoxicosis has recurrent episodes of tachycardia with severe shortness of breath. During elective surgery to remove her thyroid, she develops a heart rate of 200 with a slightly decreased blood pressure. Which of the following drugs
would be most suitable?

(A) Amiodarone
(B) Disopyramide
(C) Esmolol
(D) Quinidine
(E) Verapamil
A

(C) Esmolol

35
Q

A 16-year-old girl has paroxysmal attacks of rapid heart rate with palpitations and shortness of breath. These episodes occasionally terminate spontaneously but often require a visit to the emergency department of the local hospital. Her ECG during these episodes reveals an AV nodal tachycardia. Which
of the following drugs would be most suitable for prophylaxis of future episodes of acute AV nodal tachycardia?

(A) Adenosine
(B) Amiodarone
(C) Flecainide
(D) Propranolol
(E) Verapamil
A

(E) Verapamil

36
Q

A 55-year-old man is admitted to the emergency department and is found to have an abnormal ECG. Overdose of an antiarrhythmic drug is considered. Which of the following drugs is correctly paired with its ECG effects?

(A) Quinidine: Increased PR and decreased QT intervals
(B) Flecainide: Increased QRS interval
(C) Verapamil: Decreased PR interval
(D) Lidocaine: Decreased QRS and PR interval
(E) Metoprolol: Increased QRS duration

A

(B) Flecainide: Increased QRS interval

37
Q

A 60-year-old woman comes to the emergency department with atypical chest pain. Her ECG reveals ventricular tachycardia with rare normal sinus beats, and ST-segment elevation. Troponin C levels are markedly increased, suggesting myocardial damage. A diagnosis of myocardial infarction is
made, and the woman is admitted to the cardiac intensive care unit. Her arrhythmia will probably be treated initially with

(A) Adenosine
(B) Digoxin
(C) Lidocaine
(D) Quinidine
(E) Verapamil
A

(C) Lidocaine

emergency treatment of myocardial infarction arrhythmias

useful in digoxin-induced arrhythmias

after recovery from the acute phase of a myocardial infarction, β blockers are used for 2 years or more to prevent sudden death arrhythmias

38
Q

Which of the following drugs slows conduction through the AV node and has a duration of action of 10–20 seconds?

(A) Adenosine
(B) Amiodarone
(C) Diltiazem
(D) Esmolol
(E) Flecainide
(F) Lidocaine
(G) Mexiletine
(H) Procainamide
(I) Quinidine
A

(A) Adenosine

39
Q

When working in outlying areas, this 62-year-old rancher is away from his house for 12–14 h at a time. He has an arrhythmia that requires chronic therapy. Which of the following has the longest half-life of all antiarrhythmic drugs?

(A) Adenosine
(B) Amiodarone
(C) Disopyramide
(D) Esmolol
(E) Flecainide
(F) Lidocaine
(G) Mexiletine
(H) Procainamide
(I) Quinidine
(J) Verapamil
A

(B) Amiodarone

Pharmacology (72 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions