Drugs for Herpes Virus Flashcards
1
Q
Activated by viral thymidine kinase (TK) to forms that inhibit viral DNA
for HSV-1, HSV-2, VZV
A
Acyclovir Valacyclovir Penciclovir Famciclovir Docosanol Trifluridine
SE:
nephrotoxicity (crystalluria)
2
Q
(-) fusion b/w the HSV envelope and plasma membranes
A
Docosanol
3
Q
(-) viral DNA polymerase – chain termination
CMV, HSV-1, HSV-2, VZV
A
Ganciclovir
Valganciclovir
4
Q
(-) viral DNA polymerase – chain termination
CMV retinitis
A
Cidofovir
5
Q
(-) viral RNA polymerase, DNA polymerase and HIV reverse transcriptase
CMV retinitis
Acyclovir resistance
HSV infection in patients w/ AIDS
A
Foscarnet
SE:
nephrotoxicity
electrolyte abnormalities
GU ulceration
