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Pharmacology > Sedative-Hypnotic Drugs > Flashcards

Sedative-Hypnotic Drugs Flashcards

1
Q

Major INHIBITORY neurotransmitter

A

GABA

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2
Q

induces sleeps

A

alpha 1

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3
Q

anxiolytics

A

alpha 2

alpha 3

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4
Q

SHORT ACTING BENZODIAZEPINES

A

COMTEB

Clozapine
Oxazepam
Midazolam
Triazolam
Etizolam
Brotizolam
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5
Q

Causes ANTEGRADE AMNESIA

For PREOP SEDATION

A

Midazolam

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6
Q

INTERMEDIATE ACTING BENZODIAZEPINES

A

LATE CLN

Lorazepam (ATIVAN) - extrahepatic metabolism
Alprazolam (XANAX) - for panic attack
Temazepam
Estazolam

Clonazepam - for panic attack
Lormetazepam
Nitrazepam

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7
Q

LONG ACTING BENZODIAZEPINES

A

CCDOFFQ (Charlie Chaplin Died oF Q Fever)

Chlorazepate
Chlordiazepoxide - longest half life
Diazepam (VALIUM)
Flurazepam
Flunitrazepam - date rape drugs
Quazepam
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8
Q

MOST effective drug for stopping STATUS EPILEPTICUS

A

Diazepam

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9
Q

Abnormal sleep pattern results from the use of benzodiazepines

A

DECREASED REM SLEEP

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10
Q

Antidote for Benzodiazepines Overdose

A

FLUMAZENIL - antagonist at B2 receptors

competitive antagonist at benzodiazepine sites on GABAa receptor

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11
Q

ULTRASHORT ACTING BARBITURATES

for ANESTHESIA

A

THIOPENTAL
THIAMYLAL
METHOHEXITAL

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12
Q

SHORT ACTING BARBITURATES

A

SECOBARBITAL
HEXOBARBITAL
PENTOBARBITAL

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13
Q

INTERMEDIATE ACTING BARBITURATES

A

BAV

BUTABARBITAL
AMOBARBITAL
VINBARBITAL

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14
Q

FAST ACTING BARBITURATES

A

MEPHOBARBITAL
PHENOBARBITAL
PRIMIDONE

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15
Q

Antidote for Barbiturates Overdose

A

NaHCO3

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16
Q

Increase porphyrin synthesis by induction of hepatic delta-aminolevulinic acid synthase (ALA synthase)

A

PHENOBARBITAL

can precipitate symptoms of acute intermittent porphyria

17
Q

The MOST CATASTROPHIC SYMPTOM of sedative-hypnotic withdrawal

A

REBOUND SUICIDE

18
Q

Interact with GABAa receptors with ALPHA 1 SUBUNIT

Structurally related to Benzodiazepines

NOT used in seizures or muscle spasticity

A

SLEEP INDUCERS (for INSOMNIA)

ZOLPIDEM
ZALEPLON
ESZOPICLONE

19
Q

MOA of BUSPIRONE

for generalized anxiety disorder

A

partial agonist at 5HT1a and D2 agonist

a2, a3

PURE ANXIOLYTICS

NOT for ACUTE anxiety - slow onset of action ~ 1 week

20
Q

MOA of RAMELTEON

A

Anxiolytic Drug; Melatonin Receptor Agonist

Activates melatonin receptors (MT1 and MT2 receptors) in the suprachiasmatic nuclei in the CNS – DECREASED LATENCY OF SLEEP ONSET

for INSOMNIA

21
Q

MOA of HYDROXYZINE

A

1st generation of antihistamine that acts as an alternative to Benzodiazepines as an anxiolytic

Pharmacology (72 decks)

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