Drugs for Pneumocystosis and Toxoplasmosis

Question 1

Sequential blockade of dihydropteroate synthase and dihydrofolate reductase

Prophylaxis and treatment of PNEUMOCYTOSIS (DOC)

Recommended at CD4 <200

Answer 1

Co-Trimoxazole

SE:
GI upset
acute hemolysis in G6PD
nephrotoxicity
hypersensitivity

Question 2

Sequential blockade of dihydropteroate synthase and dihydrofolate reductase

Prophylaxis and treatment of TOXOPLASMOSIS (DOC)

Answer 2

Sulfadiazine-Pyrimethamine

Pyrimethamine + Clindamycin

Question 3

DOC for EARLY STAGE of West African Trypanosomiasis

Answer 3

Pentamidine

Question 4

DOC for CNS involvement in West African Trypanosomiasis

Answer 4

Eflornithine

Question 5

DOC for EARLY STAGE of East African Trypanosomiasis

Answer 5

Suramin

Question 6

DOC for CNS involvement East African Trypanosomiasis

Answer 6

Melarsoprol

Question 7

Inhibits glycolysis or interferes with nucleic acid metabolism

Prophylaxis for pneumocystosis

Kala-azar (visceral leishmaniasis)

Answer 7

Pentamidine

Question 8

Inhibits glycolysis or interferes with nucleic acid metabolism

Used in combination with Melarsoprol

Answer 8

Suramin

Question 9

Suicide (-) of ornithine decarboxylase

Answer 9

Eflornithine

Question 10

Organic arsenical

Inhibits enzyme sulfhydryl groups in trypanosomes

administered IM

Answer 10

Melarsoprol

Question 11

Inhibits trypanothione reductase

DOC for Leishmania

Answer 11

Nifurtimox