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Pharmacology > Skeletal Muscle Relaxants > Flashcards

Skeletal Muscle Relaxants Flashcards

1
Q

Neuromuscular paralysis that results from persistent depolarization of the end plate

A

Depolarizing or Stabilizing Blockade

SUCCINYLCHOLINE

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2
Q

Competitive antagonists at the acetylcholine receptor end plate

A

Nondepolarizing Neuromuscular Blockers

TUBOCURARINE
MIVACURIUM
ATRACURIUM
CISATRACURIUM
VECURONIUM
ROCURONIUM
PANCURONIUM
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3
Q

Skeletal muscle relaxants that undergo HOFFMAN ELIMINATION

rapid spontaneous breakdown – yielding LAUDANOSINE – SEIZURES

A

ATRACURIUM

CISATRACURIUM

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4
Q

Causes reversal of effects of Atracurium and Cisatracurium

A

NEOSTIGMINE

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5
Q

Neuromuscular blockers considered as DOC for hemodynamically compromised patients

A

CISATRACURIUM
VECURONIUM
ROCURONIUM

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6
Q

Novel reversal agent specifically for ROCURONIUM

A

SUGAMMADEX

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7
Q

Drugs used in LETHAL INJECTION

A

Thiopental - 5 g
Pancuronium - 100 mg
Potassium chloride - 100 mEq

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8
Q

NMB choice for RAPID SEQUENCE INDUCTION

A

SUCCINYLCHOLINE

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9
Q

Measure of the ability of a patient to metabolize succinylcholine/mivacurium

Reflects the QUALITY of cholinesterase enzyme

A

Dibucaine number

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10
Q

MOA of BACLOFEN

A

centrally acting spasmolytic drugs

GABAb AGONIST

for severe spasticity d.t. cerebral palsy, multiple sclerosis, stroke

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11
Q

MOA of DANTROLENE

A

direct acting muscle relaxant

blocks RyR1 calcium release channels in the sarcoplasmic reticulum of the skeletal muscle

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12
Q

MOA of EPERISONE

A

antispasmodic drug which RELAXES both skeletal and vascular smooth muscles and reduces myotonia, improves circulation and suppresses pain reflex

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13
Q

Drugs used in Lethal Injection

A

TPP

Thiopental
Pancuronium
Potassium chloride

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14
Q

Succinylcholine + Halothane can cause

A

MALIGNANT HYPERTHERMIA

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15
Q

Treatment for Malignant Hyperthermia

A

Dantrolene

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16
Q

SHORT ACTING Non Depolarizing Blockers

A

Mivacurium
Atracurium
Cisatracurium

17
Q

INTERMEDIATE ACTING Non Depolarizing Blockers

A

Vecuronium

Rocuronium

18
Q

LONG ACTING Non Depolarizing Blockers

A

Pancuronium

Tubocurarine

19
Q

SE of Non Depolarizing Blockers

A

Respiratory paralysis

+ Aminoglycosides - potentiates paralysis

20
Q

Centrally Acting Spasmolytics

A 
Baclofen
Diazepam
Tizanidine
Orphenadrine
Chlorphenesin
Methocarbamol
Cyclobenzaprine
21
Q

Centrally Acting Spasmolytics

GABAb agonist
Facilitates spinal inhibition of motor neurons

A

Baclofen

22
Q

Centrally Acting Spasmolytics

Facilitates GABAergic transmission in CNS

for chronic spasm d.t. Cerebral Palsy, stroke etc.

A

Diazepam

23
Q

Centrally Acting Spasmolytics

Alpha 2 agonist in the spinal cord

A

Tizanidine

24
Q

Direct Acting Muscle Relaxants

A

Dantrolene

Eperisone

Pharmacology (72 decks)

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