Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Drugs Used in Peptic Ulcer Disease > Flashcards

Drugs Used in Peptic Ulcer Disease Flashcards

1
Q

MOA of Antacids

A

react w/ protons in the lumen of the gut

neutralizes the produced acids

(+) mucosal prostaglandin production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ANTACIDS

A

Magnesium Hydroxide
Aluminum Hydroxide
Sodium Bicarbonate
Calcium Carbonate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Measures POTENCY of antacids

A

ACID NEUTRALIZING CAPACITY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

pH goal for healing ulcer

A

pH - 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

pH goal for stress ulcer

A

pH - 4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

pH goal for bleeding ulcer

A

pH - 6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Adverse effects of Sodium Bicarbonate

A

belching - HCO3 –> CO2
worsens HPN
milk alkali syndrome - metabolic alkalosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Adverse effects of Calcium Carbonate

A

belching
hypercalcemia
nephrolithiasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Adverse effects of Aluminum Hydroxide

A

ALang tae

constipation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Adverse effects of Magnesium Hydroxide

A

MAGtatae

diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MOA of H2 ANTAGONISTS

A

(-) basal acid production

(-) prandial acid release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

H2 ANTAGONISTS

A

Cimetidine
Ranitidine
Famotidine
Nizatidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

H2 antagonists w/ THIAZOLE ring

oral but w/ almost 100%

A

FAMOTIDINE

NIZATIDINE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

H2 antagonist w/ FURAN ring

A

RANITIDINE

mostly used

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

H2 antagonist w/ IMIDAZOLE ring

A

CIMETIDINE

1st H2 blockers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

H2 antagonist that can cause endocrine side effects (alopecia, loss of libido, impotence, irregular menstruation)

A

CIMETIDINE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

MOA of Proton Pump Inhibitors (PPI)

A

IRREVERSIBLY (-) H K ATPase pump

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Proton Pump Inhibitors (PPIs)

fast acting and long duration - once a day dosing

ENTERIC COATED

A 
Omeprazole
Esomeprazole
Lansoprazole
Pantoprazole
Rabeprazole
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

All PPIs are renally excreted EXCEPT

A

Lansoprazole - biliary excretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

MOA of MISOPROSTOL

A

Prostaglandin Analog

INC MUCUS/HCO3

uterine contraction
abortifacient

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

MOA of SUCRALFATE

A

sucrose complex w/ sulfated aluminum hydroxide

binds to injured tissue and forms a protective covering over ulcer beds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Side effects of SUCRALFATE

A

constipation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

MOA of BISMUTH SALICYLATE

A

Slurry prep

Coats the mucosa

24
Q

Mucosal protectant w/ ANTIMICROBIAL EFFECTS

A

BISMUTH SALICYLATE

25
Q

Side effects of BISMUTH SALICYLATE

A

ASA hypersensitivity
BLACK STOOLS
DARKENING of TONGUE
ENCEPHALOPATHY - ataxia, headaches, confusion, seizures

26
Q

PROMOTE GASTRIC MOTILITY

A

GAM

gastrin
Ach
motilin

27
Q

INHIBIT GASTRIC MOTILITY

A

Dopamine

Di gagalaw

28
Q

Cholinergic Agonists (PARA)

A

DIRECT
Pilocarpine
Betanechol

INDIRECT
Neostigmine

29
Q

D2 Antagonists

A

METOCLOPRAMIDE

crosses BBB; antiemetic
for gastroparesis

DOMPERIDONE

does NOT cross BBB
for (+) of postpartum lactation and gastroparesis

30
Q

Side effects of Metoclopramide

A

extrapyramidal symptoms (EPS)

endocrine side effects

  • dopamine
  • D2 antagonists –> DEC DOPA –> INC prolactin

galactorrhea

31
Q

Motilin Stimulator

promotes MOTILIN release

A

MACROLIDE

ERYTHROMYCIN

32
Q

BULK FORMING LAXATIVES

absorb H20 –> SOFTEN and ENLARGE stool –> fecal swelling –> PROMOTES PERISTALSIS

PWEDENG FOR CHRONIC USE

A

Psyllium
Methylcellulose
Polycarbophil

33
Q

OSMOTIC LAXATIVES

causes DUODENAL SECRETION of CCK –> INC fluid secretion and motility

poorly absorbed
salts remain in fecal matter –> pull H20 into the lumen

A

Lactulose
Magnesium Oxide
Sorbitol
Magnesium Citrate

34
Q

SURFACTANT (STOOL SOFTENING) LAXATIVES

lowers surface tension
facilitates H20 penetration –> liquefaction of stool

A

Docusate
Glycerin Suppository
Mineral Oil

35
Q

STIMULANT/CATHARTIC LAXATIVES

(+) peristalsis

A

Bisacodyl
Aloe
Senna
Castor Oil

36
Q

Side effects of Senna

A

MELANOSIS COLI

  • benign disorder of colonic pigmentation
  • d.t. intake of anthraquinone-containing laxative (SENNA)
37
Q

LUBRICANT LAXATIVES

(-) H20 and fat absorption

A

Mineral Oil

38
Q

ANTIFLATULENT

A

Al (OH)3(MgOH)2 - Simethicone

39
Q

BOWEL EVACUANT

A

Polyethylene glycol
Sodium phosphate
ENEMA (fleet)

40
Q

Loperamide

stimulates opioid receptors in enteric nervous system

slows motility w/ negligible CNS effects

A 
Diphenoxylate
Kaolin + Pectin
Colloidal Bismuth
Difenoxin
Loperamide
41
Q

MOA of 5 HT3 RECEPTOR ANTAGONISTS

5 HT3 receptor - located on the CTZ on the floor of the 4th ventricle of the brain

A 
Ondansetron
Granisetron
Dolasetron
Palonosetron
Alosetron
Tropisetron

blocks chemoreceptor trigger zone (CTZ) and enteric nervous system

42
Q

Drugs used in IBD that (-) synthesis of prostaglandin and leukotrienes

Immunomodulator

A

Mesalamine (5-ASA) - 5-aminosalicylic acids
Balsalazide
Sulfasalazine - causes SJS
Mesalazine

43
Q

Pentasa (Mesalamine)

A

JEJUNUM to RECTUM

44
Q

Sulfasalazine

Mesalazine

A

COLON

45
Q

Asacol (Mesalamine Delayed-Release Tablets)

Lialda (Mesalamine)

A

ILEUM to RECTUM

46
Q

Rowasa (Mesalamine Rectal Suspension Enema)

A

SIGMOID TO RECTUM

47
Q

Canasa (Mesalamine)

A

RECTUM

48
Q

MUCOSAL PROTECTIVE AGENTS

A

Sucralfate
Misoprostol
Bismuth Salicylate

49
Q

TRIPLE THERAPY

A

Bismuth subsalicylate PLUS
Metronidazole PLUS
Tetracycline

Ranitidine bismuth citrate PLUS
Tetracycline PLUS
Clarithromycin or Metronidazole

Omeprazole PLUS
Clarithromycin PLUS
Metronidazole OR
Amoxicillin

50
Q

SE of PPI

A 
diarrhea
headache
abdominal pain
malabsorption - daily long term use (3 years) -- Vit B12 deficiency
infections
hypergastrinemia
atrophic gastritis
fractures of hip and spine (increases risk for osteoporosis)
51
Q

QUADRUPLE THERAPY

A

Tetracycline
Omeprazole
Metronidazole
Bismuth subsalicylate

52
Q

PROKINETIC AGENTS

block D2 receptors

stimulates motilin receptors

A

Metoclopramide
Domperidone
Erythromycin

53
Q

ANTIDIARRHEAL AGENTS

Activates opioid receptors in enteric nervous system

Slows motility with negligible CNS effects

A

OPIOID:
Diphenoxylate
Loperamide

NON OPIOID:
Kaolin + Pectin, Colloidal bismuth, Difenoxin

54
Q

Decreases the cholesterol content of bile by reducing cholesterol secretion

USES:
Dissolution of small cholesterol gallstones in patients with symptomatic gallbladder disease who refuse surgery or are poor surgical candidates

A

Ursodiol (Ursodeoxycholic Acid) - URSA

55
Q

Metabolized to bicarbonate – alkalinizes urine and raises urinary citrate

USES:
Hypocitraturic calcium oxalate nephrolithiasis
Renal tubular acidosis with calcium stones
Uric acid lithiasis

A

Potassium citrate

SE:
hyperkalemia
abdominal discomfort
vomiting/nausea
diarrhea
LBM

Pharmacology (72 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions