Sympatholytics Flashcards
Nonselective Alpha Blockers
Irreversible (a1>a2)
for pheochromocytoma
SE: orthostatic hypotension, reflex tachycardia
Phenoxybenzamine
Nonselective Alpha Blockers
Reversible (a1 = a2)
for pheochromocytoma, antidote for a1 agonist overdose
SE: orthostatic hypotension, reflex tachycardia
Phentolamine
Tolazoline
Selective Alpha Blockers
alpha 1 blocker
for BPH, HPN
SE: 1st dose orthostatic hypotension, LITTLE reflex tachycardia
PraZOSIN DoxaZOSIN TeraZOSIN TamsulOSIN - most selective for prostatic smooth muscle SiladOSIN AlfuzOSIN
Can cause INTRAOPERATIVE FLOPPY IRIS SYNDROME (IFIS) in patients undergoing cataract surgery
Tamsulosin
Nonselective Beta Blocker
blocks B1 and B2
(-) sympathetic effects on heart and BP
reduces renin release
Propranolol Pindolol Timolol Nadolol Levobunolol Metipranolol Carteolol Sotalol Labetalol Carvedilol
Selective Beta Blocker (B1 blocker/ Cardioselective BB)
NBBEAAAMC
NEBIVOLOL Bisoprolol Betaxolol Esmolol Atenolol Acebutolol Alprenolol Metoprolol Celiprolol
Selective Alpha Blockers
alpha 2 blocker
Yohimbine
Selective B2 Blockers
Butoxamine
Betablockers with Intrinsic Sympathomimetic Activity (ISA)
ISA - CLAP
Carteolol Celiprolol Acebutolol Penbutol Pindolol
Bopindolol
Oxprenolol
Betablockers with NO Local Anesthetic Activity (Membrane Stabilizing Activity)
useful in glaucoma
Timolol
Betaxolol
Shortest acting BB
Esmolol
Longest acting BB
Nadolol
Combined alpha and beta blockade
Nebivolol
Carvedilol
Labetalol
Principal CONTRAINDICATION to beta blocker use
preexisting AV heart block or cardiac failure NOT caused by tachycardia
