Glycopeptides Flashcards
1
Q
Inhibits cell wall synthesis by BINDING to D-Ala D-Ala terminus
Inhibits transglycosylase (prevents elongation and crosslinking)
A
POLYPEPTIDES
2
Q
Polypeptides
A
VANCOMYCIN
Teicoplanin
Dalbavancin
Telavancin
3
Q
Adverse side effect associated with VANCOMYCIN
A
RED MAN SYNDROME
*red pruritic rash on torso d.t. rapid IV infusion
4
Q
Binds to bacterial membrane causing rapid membrane depolarization – (-) DNA, RNA and protein synthesis
A
Daptomycin
*gram (+) - sepsis and endocarditis
5
Q
DOC for MRSA and pseudomembranous colitis
A
Vancomycin
*nephrotoxic
6
Q
Not absorbed in the GIT and used for bacterial enterocolitis
A
Teicoplanin
Telavancin
7
Q
VRSA and VSE are d.t.
A
D-Ala-D lactate formation
8
Q
Has VERY LONG half life (6-11 days) which permits once weekly dosing
A
Dalbavancin
