Antidepressants Flashcards
TRICYCLIC ANTIDEPRESSANTS (TCA)
- PRAMINE
- TYPTYLINE
(-) neuronal reuptake serotonin and NE
for depression not responsive to SSRI and SNRI
for chronic pain
Imipramine Clomipramine Desipramine Amitryptyline Nortryiptyline
SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIs) – 1st line
(-) neuronal reuptake by serotonin by (-) serotonin transporter (SERT)
DOC for Major Depressive Disorder
Fluoxetine Escitalopram Paroxetine Citalopram Sertraline Fluvoxamine -- approved only for OCD Viladozone
SEROTONIN - NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs)
(-) reuptake of NE and serotonin
for chronic pain, fibromyalgia and menopausal symptoms
Duloxetine
Venlafaxine
Desvenlafaxine
Milnacipran
SEROTONIN RECEPTOR ANTAGONISTS
-DOZONE
blocks 5-HT2 receptors
for hypnosis
anxiety disorders, sleeping aid
Nefazodone
Trazodone
Vortioxetine
SE:
priapism
HETEROCYCLIC (TETRACYCLIC)
ANTIDEPRESSANTS
Amoxapine
Bupropion
Maprotiline
Mirtazapine
MONOAMINE OXIDASE INHIBITOR (MAOIs)
(-) MAO-A and B
for MDD unresponsive to other drugs
Phenelzine
Tranylcypromine
Isocarboxazid
Selegiline
TCA toxicity
Coma
Convulsions
Cardiotoxicity
SE of TCA
Anticholinergic effects
Histamine block – sedation and weight gain
Alpha blockade – orthostatic hypotension
SE of SSRI
Serotonin syndrome (if co administered with MAOI)
Paroxetine and Sertraline - discontinuation syndrome
Citalopram - QT prolongation and teratogen
SE of SNRI
Venlafaxine - HPN
Duloxetine - hepatotoxicity
Heterocyclic Antidepressant
strong NE reuptake inhibitor
blocks D2 receptors
resemble TCA in terms of effects
Amoxapine - lower seizure threshold
Maprotiline
Heterocyclic Antidepressant
increases amine release from nerve endings by antagonism of presynaptic alpha2 adrenoceptors
blocks serotonin 5HT2 receptors
for sedation/sleeping aid
Mirtazapine
SE:
weight gain
Heterocyclic Antidepressant
(-) neuronal reuptake of dopamine and NE
for smoking cessation
Bupropion
