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Flashcards in Anti-Tumor Agents Deck (21):
1

Roughly ____ of all leukemia and lymphoma patients are cured.

2/3

2

Neoadjuvant therapy is _______.

treating someone with chemotherapy prior to surgery or radiation (for anal, bladder, breast, esophageal, head and neck, gastric, rectal, and osteosarcoma)

3

Adjuvant therapy is _______.

drug treatment after surgery or radiation

4

Chemotherapy is difficult because ________.

most chemotherapeutics have small therapeutic windows, side effects vary, and patients have different pharmacokinetics (due to renal or hepatic dysfunction)

5

When combining chemotherapies, avoid mixing drugs that have _________.

similar toxic effects, for instance two drugs that impact kidney function

6

Generally, oncologists give patients the _______ of traditional, cytotoxic agents.

maximally targeted dose

7

The most frequently used alkylating agent is ________.

cyclophosphamide

8

Patients with up-regulated concentrations of glutathione or aldehyde dehydrogenase are resistant to ________.

alkylating agents such as cyclophosphamide

9

Cisplatins work by __________.

cross-linking DNA strands

10

______ are toxic to the kidneys and ears.

Cisplatins

11

5-fluorouracil works by ________.

mimicking DNA imperfectly, leading to DNA damage and apoptosis

12

Doxorubicin is a ______.

topoisomerase II inhibitor

13

VIncristine and vinblastine are _________.

microtubule inhibitors

14

Paclitaxol and docetaxel are ______.

microtubule stabilizers

15

Drug resistance to chemotherapies can occur by ________.

mutations that deactivate the drug, alter the drug target, respond adaptively to the drug target, or resist apoptosis

16

How to alkylating agents work?

They introduce DNA damage that can signal the cell to apoptose (if apoptosis pathways are not mutated)

17

Alkylating agents can be neutralized by _______.

cellular molecules like glutathione

18

The platins are very toxic to the _________.

kidneys and inner ears

19

_________ can cause secondary malignancies.

Topoisomerases (6%)

20

List three side effects of taxanes.

Neutropenia, alopecia, and peripheral neuropathy

21

One side effect of tamoxifen is _______.

decreased bone density

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