Antiviral Agents Flashcards Preview

Disease & Defense > Antiviral Agents > Flashcards

Flashcards in Antiviral Agents Deck (21):
1

What does neuraminidase do?

It cleaves the N-acetyl neuraminic from host-cell receptors, leading to viral budding.

2

______ and ________ inhibit neuraminidase.

Oseltamivir; Zanamivir

3

How effective is Oseltamivir in preventing influenza?

70% - 90%

4

All of the -amivir drugs act to inhibit ______.

neuraminidase

5

Zanamivir can impair ___________.

lung function, by inducing cough and bronchospasm

6

Amantadine and rimantadine both act on _________.

viral h+ pumps, which are required for uncoating in the cytoplasm

7

Rimantadine cannot get into the _______ very well.

CNS

8

Valacyclovir, acyclovir, and ganciclovir all work by ________.

creating acyclovir triphosphate, which mimics DNA and disrupts viral DNA production

9

All of the acyclovir drugs only work on ________.

viruses that utilize thymidine kinase (this is the first phosphorylation step)

10

Acyclovir is ________ eliminated.

renally (thus adjust dose in infants and those with renal impairment)

11

Ganciclovir works in a similar way to _______, but has the side effects of ______.

valacyclovir and acyclovir; bone marrow depression

12

Cidofovir works by _________, but it has the negative side effect of ________.

mimicking nucleotides that viral DNA polymerases use; nephrotoxicity

13

What two drugs block HIV entry?

Enfuvirtide and maraviroc

14

What drug blocks HSV entry?

Docosanol

15

Palivizumab blocks the entry of which virus?

RSV

16

Valacyclovir requires a __________ to be activated.

phase I esterase

17

Which two viral-DNA disruptors can only be given topically?

Penciclovir and vidarabine-trifluridine

18

RSV can be treated with _____, a nucleoside analog, but because of adverse effects should be restricted to the more severe cases.

ribavirin

19

What two drugs are used to treat CMV?

Ganciclovir and valganciclovir

20

Which DNA mimetic does not require cellular activation?

Foscarnet

21

Which has better absorption, acyclovir or valacyclovir?

Valacyclovir

Decks in Disease & Defense Class (59):