Inflammatory Mediators Review Flashcards Preview

MS1 - Disease & Defense > Inflammatory Mediators Review > Flashcards

Flashcards in Inflammatory Mediators Review Deck (11):
1

Rolling is mediated by ________.

selectins

2

Adhesion is mediated by _______.

integrins (ICAM-1)

3

Which inflammatory mediators are cell-derived?

Histamine, serotonin, prostaglandins, leukotrienes, platelet-activating factor, cytokines, chemokines, nitric oxide, and reactive oxygen species

4

Which inflammatory mediators are plasma-protein derived?

Complement, kinins, and proteases activated during coagulation

5

The two main inflammatory receptors are _________.

TLRs and inflammasomes

6

What induces histamine release?

Physical stress, IgE, C3a, C5a, IL-1, and IL-8

7

Endothelial activation is mediated by ______.

TNF (released by M1 macrophages), IL-1 (released by M1 macrophages), histamine (released by mast cells), and thrombin

8

The three most important opsonizing agents are ______.

IgG, C3b, and mannose-binding lectin

9

_______ and _______ are TNF inhibitors.

Infliximab (Remicade) and etanercept (Enbrel)

10

List five anti-inflammatory factors.

C1 inhibitors, alpha-1-antitrypsin, IL-10, TGF-beta, and lipoxins

11

What is the link between the clotting cascade, the kinin cascade, the complement cascade, and the fibrinolytic cascade?

Hageman Factor XII

Decks in MS1 - Disease & Defense Class (59):