Flashcards in Inflammatory Mediators Review Deck (11):
Rolling is mediated by ________.
Adhesion is mediated by _______.
Which inflammatory mediators are cell-derived?
Histamine, serotonin, prostaglandins, leukotrienes, platelet-activating factor, cytokines, chemokines, nitric oxide, and reactive oxygen species
Which inflammatory mediators are plasma-protein derived?
Complement, kinins, and proteases activated during coagulation
The two main inflammatory receptors are _________.
TLRs and inflammasomes
What induces histamine release?
Physical stress, IgE, C3a, C5a, IL-1, and IL-8
Endothelial activation is mediated by ______.
TNF (released by M1 macrophages), IL-1 (released by M1 macrophages), histamine (released by mast cells), and thrombin
The three most important opsonizing agents are ______.
IgG, C3b, and mannose-binding lectin
_______ and _______ are TNF inhibitors.
Infliximab (Remicade) and etanercept (Enbrel)
List five anti-inflammatory factors.
C1 inhibitors, alpha-1-antitrypsin, IL-10, TGF-beta, and lipoxins