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Flashcards in Common Viral Pathogens Deck (35):
1

Herpetic whitlows are _________.

herpes vesicles on the fingers (occupational hazard for clinicians)

2

Genital herpes lesions are usually _____, unlike those from syphilis.

painful

3

One side effect of neonatal herpes is __________.

SEM syndrome (skin, eyes, membranes); can lead to blindness

4

Neonatal herpes can also result in _________.

CNS symptoms (encephalitis) and disseminated symptoms (DIC, lung, eye, skin involvement)

5

Herpes is treated with ________.

acyclovir (sometimes too late), C section (for mothers who have herpes, to prevent infection)

6

What are some complications of VZV?

Hepatitis, encephalitis, pneumonia, necrotizing fasciitis, secondary infections, congenital varicella syndrome

7

VZV is worse in _______ patients.

older

8

In addition to acyclovir, ______ is given to VZV patients to reduce symptoms.

varizig (immunoglobulin)

9

Unlike other herpes viruses, VZV is not _________ unless the patient is symptomatic.

infectious

10

People older than 65 account for __________ of influenza deaths.

>90%

11

The flu kills roughly ______ people per year.

3,000 - 50,000

12

What are the three kinds of flu virus, and what species does each affect?

A, B, and C; B and C only affect humans (and they are less severe), while A affects lots of species and is responsible for pandemics

13

Flu virus binds to human _________ receptors using their _______.

sialic acid; hemagglutinin

14

Antigenic drift is ___________, while antigenic shift is __________.

a point mutation that results in a different, potentially more vicious virus (will be the same species, though); a mixing of viruses to produce a new strain

15

The _____ protein of RSV allows the virions to bind to cells and also leads to the ______.

F; syncytia, characteristic of RSV

16

____ RSV is usually worse than ______.

A; B

17

RSV primarily replicates in ________.

respiratory epithelium

18

All of the herpes viruses are _______.

dsDNA viruses, icosahedral, and surrounded by a glycoprotein coat

19

The alpha subfamily of herpes (which includes ______) lies dormant in ______.

HSV1, HSV2, and VZV; sensory ganglia

20

Herpes beta viruses (__________) infect ________.

CMV, HHV-6, and HHV-7); monocytes and lymphocytes

21

Viruses in the gamma subfamily of herpes (i.e., __________) infect _________.

EBV and KSV; B cells

22

While acyclovir and ganciclovir act on viral thymidine kinase, _________ acts on the viral DNA polymerase.

foscarnet

23

Most primary HSV infections are not ________.

symptomatic

24

What causes keratitis?

HSV-1

25

What virus should you be thinking if a question has a patient with temporal-lobe encephalitis?

HSV-1 (or HSV-2 if it's a neonate)

26

Considering HSV, IV acyclovir should be given to those who _________.

are neonates, have encephalitis, or are immunocompromised

27

What kind of vaccine is the chickenpox vaccine?

Live attenuated

28

The shingles vaccine is the same as the chickenpox vaccine but contains ______.

more virus (14x)

29

CMV is transmitted through ________.

contact with infected bodily fluids

30

In non-immunocompromised individuals, CMV causes _________.

fever and/or mononucleosis

31

Influenza's genome is _________.

eight pieces of single-stranded RNA

32

The H and N in H1N1 (and other flu names) stand for _______.

types of hemagglutinin and neuraminidase

33

The incubation period for flu is typically ______.

1-3 days

34

Amantadine and rimantadine are types of __________.

matrix protein inhibitors

35

What kinds of flu vaccine are there?

Inactivated (given as a shot, ok for everyone 6 months or older) and live (given nasally to those 2 and older)

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