Flashcards in Pharmacokinetics - Drug Absorption Deck (10)
List the four factors that affect drug absorption.
Molecular size; lipid solubility; ionization; and concentration gradient.
The most common method of drug absorption is ______.
lipid diffusion through the membrane
Bioavailability is also called _______.
extent of absorption
F (fraction bioavailable) = _____.
(AUC route) / (AUC iv)
First pass effect is best described as ______.
the hepatic or gastric metabolism of a drug prior to entry in to the systemic circulation
Rate of drug absorption can be decreased by ________.
coating pills in enteric products
A generic product is bioequivalent to a brand product if _____ are within set limits.
the rate (estimated by Cp and Tmax) and extent (bioavailable portion)
Drugs that are _______ have high bioavailability.
hydrophobic but stable in aqueous solutions
The most bioavailable and fast route is ___.