Pharmacokinetics - Drug Absorption Flashcards Preview

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Flashcards in Pharmacokinetics - Drug Absorption Deck (10):
1

List the four factors that affect drug absorption.

Molecular size; lipid solubility; ionization; and concentration gradient.

2

The most common method of drug absorption is ______.

lipid diffusion through the membrane

3

Bioavailability is also called _______.

extent of absorption

4

F (fraction bioavailable) = _____.

(AUC route) / (AUC iv)

5

First pass effect is best described as ______.

the hepatic or gastric metabolism of a drug prior to entry in to the systemic circulation

6

Rate of drug absorption can be decreased by ________.

coating pills in enteric products

7

A generic product is bioequivalent to a brand product if _____ are within set limits.

the rate (estimated by Cp and Tmax) and extent (bioavailable portion)

8

Drugs that are _______ have high bioavailability.

hydrophobic but stable in aqueous solutions

9

The most bioavailable and fast route is ___.

IV

10

Does transdermal or dermal absorb systemically?

Transdermal

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