Cell Growth and Neoplasia Flashcards Preview

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Flashcards in Cell Growth and Neoplasia Deck (20):
1

Give an example of physiologic hypertrophy.

The uterus expanding during pregnancy

2

Give an example of pathologic hypertrophy.

The heart expanding during prolonged hypertension

3

______ is an example of physiologic hyperplasia.

Breast growth during puperty

4

In Barrett's esophagus, normal ______ cells transition to ______ cells.

squamous; columnar (intestinal are higher risk than gastric)

5

Smokers often have a type of metaplasia in which _________.

normal, columnar bronchus cells transition to squamous cells

6

Although we often think of cell-autonomous factors with neoplasia, like ______, there are also extrinsic causes such as ______.

oncogenes and tumor suppressors; circulation of cytokines or changes in the micro-environment

7

List some features of benign neoplasms.

Well differentiated, low rate of cell turnover, cytologic uniformity, boundary between neoplasm and surrounding tissue, less necrosis.

8

List some features of malignant neoplasms.

Varying differentiation, high rate of turnover, cytologic polymorphism, less boundary between neoplasm and surrounding tissue, common necrosis.

9

Sarcomas are ______.

malignant tissues of mesenchymal origin (e.g., osteosarcoma, fibrosarcoma, chondrosarcoma)

10

Carcinomas are ________.

malignant neoplasms of epithelial origin (e.g., adenocarcinoma)

11

Adenomas are _________.

neoplasms of glandular tissue

12

Give some examples of benign neoplasias of mesenchymal origin.

Fibroma, osteoma, chondroma

13

Asbestos increases the incidence of _______.

mesothelioma in the lungs

14

Inflammatory bowel disease leads to a _______.

20-fold increase in the relative risk for colorectal cancer

15

List the six characteristic actions of cancer.

Evades apoptosis, sustains angiogenesis, invades tissue, is insensitive to anti-growth signals, has a limitless replication potential, and can self-signal for growth

16

Cancers of _____ tissue are most common.

epithelia (which are carcinomas)

17

Dysplasia is _____.

disordered growth (as evinced by loss of cytologic uniformity, loss of cell architecture)

18

Low-grade histologic indicates ______.

high degree of differentiation

19

High-grade histology indicates _______.

low degree of differentiation (worse prognosis)

20

Morphogenesis is another name for _______.

development

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