Flashcards in Pharmacokinetics - Drug Distribution Deck (7)
What are the three sites in which epithelial cells are tightly linked together--through which drugs cannot pass through fenestrations?
The GI tract, the CNS, and renal tubules
Strong acids have _____ pKas.
low (HI has a pKa of -10)
Strong bases have _____ pKas.
high (OH- has a pKa of 15.7)
When pH>pKa, the _______ form dominates.
Protein binding ____ the free concentration and _____ the degradation.