Pharmacokinetics - Drug Distribution Flashcards Preview

MS1 - Disease & Defense > Pharmacokinetics - Drug Distribution > Flashcards

Flashcards in Pharmacokinetics - Drug Distribution Deck (7):
1

What are the three sites in which epithelial cells are tightly linked together--through which drugs cannot pass through fenestrations?

The GI tract, the CNS, and renal tubules

2

Strong acids have _____ pKas.

low (HI has a pKa of -10)

3

Strong bases have _____ pKas.

high (OH- has a pKa of 15.7)

4

When pH>pKa, the _______ form dominates.

deprotonated

5

When pH

protonated

6

Protein binding ____ the free concentration and _____ the degradation.

reduces; slows

7

Vd (volume of distribution) is equal to ______.

(amount of drug in patient) / (extrapolated concentration at time zero)

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