Lec 11-2 - Pharm Manipulation Flashcards Preview

Dental Microbiology > Lec 11-2 - Pharm Manipulation > Flashcards

Flashcards in Lec 11-2 - Pharm Manipulation Deck (22):
1

methotrexate is specific for the blank phase of division

S

2

mechanism of action of steroids

lipid soluble compounds diffuse across cell membranes and bind cystolic receptors, dimer of heat shock protein displaced, exposing dna binding region of receptor, binds to regulatory gene and activates transcription

3

methotrexate treats this

arthritis, first line of defense against any immune disorder

4

rare form of necrotizing vasculitis

wegeners granulomatosis

5

males or females are more likely to get wegeners granulomatosis

men

6

cyclophosphamide is a blank drug so it enzymatically activates a phosphoramide mustard which destroys dna

pro drug

7

drug that must be taken with a lot of water due to bladder toxicity

cytoxan

8

azathioprine is a blank that blocks blank synthesis

pro drug, purine

9

treatment of unwanted immune responses that occur in autoimmune disease and transplant rejection

extrinsic regulation

10

examples of antimetabolite agents

methotrexate azathioprine

11

example of alkylating agents

cyclophosphamide

12

prednisone is a blank

corticosteroid

13

adverse effects of corticosteroids

fluid retention, diabetes, weight gain, bone mineral loss, thinning of skin

14

cyclosporin A, rapamycin, fk506 are all derived from blank

fungal, bacterial

15

new set of inhibitors for treating RA

JAK inhibitors

16

cyclosporin A binds to blank and inhibits blank

cyclophilins, calcineurin

17

tacrolimus binds to blank

fk binding proteins

18

***inhibition of blank suppresses immune response by blocking activation step of interleukin synthesis

calcineurin

19

cytotoxic drugs are toxic to blank which are the cells responsible for the autoimmune disorder

dividing lymphocytes

20

one of the chemical messengers that helps regulates the inflammatory process

tumor necrosis factor

21

tnf alpha induces

pro inflammatory cytokines and everything else that contributes to inflammation

22

tnf alpha inhibitors treat blank but these are some side effects

ra, headache, rash, swelling, infections