Lec 7 Humoral Immunity Flashcards Preview

Dental Microbiology > Lec 7 Humoral Immunity > Flashcards

Flashcards in Lec 7 Humoral Immunity Deck (30):
1

primary response has blank b cell activation, main isotype is blank, and the antigens are both thymic blank and blank

naive, IgM, dependent, independent

2

secondaryresponse has blank b cell activation, main isotype is blank, and the antigens are thymic blank

memory, IgG, dependent

3

progressive change in ig class of specific antibody

isotype switch

4

isotype switch is usually blank to blank

igM --> igG

5

isotype switching is dependent on blank cells

t

6

degree of blank is inversely related to dose of antigen and this is associated with igM to igG switch

affinity maturation

7

under low antigen conditions, b cells with blank affinity receptors for the antigen will bind it

high

8

for t dependent reaction of activating b cells these signals are needed

one from antigen, one from complement breakdown of antigens, one from helper t

9

B cell signals through receptor and co-receptor supplemented through T cell interactions and signals

t dependent

10

B cell signals through receptor and co-receptor amplified by multiple epitopes and more extensive surface immunoglobulin cross-linking

t independent

11

surface ig has a very short blank tail so it cannot promote blank

cytoplasmic, signals

12

2 signaling molecules that carry out signals through motifs on their tails

IgAlpha, IgBeta

13

Most receptors trigger signaling by blank of existing signaling molecules

post translational modification

14

blank are central as it relates to signaling kinases

protein tyrosine kinases

15

Phosphorylation of receptor cytoplasmic tails serves to blank signaling molecules around the receptors

recruit

16

kinases transfer blank from high energy containing compound such as ATP to a blank

phosphates, substrate

17

Signaling molecules have domains that bind to blank and surrounding protein sequences

phosphotyrosine

18

in the b cell receptor, blank leads to activation of several blank and these phosphorylate blank on the ITAM motifs

antigen cross linking, tyrosine kinases, igAlpha/igBeta

19

b cell activation takes place in germinal centers in blank or blank

spleen, lymph nodes

20

follicular dendritic cells are no blank and keep antigens intact for presentation

phagocytic

21

some b cells undergo rapid division and produce blank

igM

22

R: a functional response to a T cell dependent antigen B cell response requires BCR and B cell co-receptor activation + T cell Help in the form of cytokines

alright

23

R: Responses to repetitive blank can cause extensive crosslinking and can allow a T independent response

carbohydrates

24

R: B cells with blank affinity Ag receptors are selected for survival

high

25

R: During passage through germinal centers, B cells express the survival gene blank

bcl-2

26

R: Cells with high affinity blank are saved from apoptosis by ligation of bcl-2; all others die

igG

27

R: memory b cells are usually activated by very low amounts of blank

antigen

28

memory b cells are posibly modulated by blank to develop from precursors to memory cells

cytokines

29

primary response is blank than secondary

slower lower

30

igAlpha and igBeta are transmembrane signaling molecules associated with surface blank

igM