Flashcards in Lec 4 - Generation Of Antibody Diversity Deck (20):
1
Three levels of antibody diversity
Antibody binding, isotype switch, membrane interactions
2
Each b cell clones produces one unique set of blank and blank
Ig heavy chain, variable chain
3
Different portions of an immunoglobulin molecule are encoded by different genes and different combinations of these genes contribute to diversity
Alternative theory
4
Heavy and light chains are encoded by different blank
Genes
5
Different variable region genes are combined with different blank region genes
Constant
6
V regions are like interchangeable screwdriver blank
Tips
7
Additional short segment of dna which in b cells is joined to the V DNA between the C and V dna segments during gene rearrangement
J segments
8
This segment is involved in heavy chains gene rearrangement
D (diversity) segmnet
9
Different blank segments of germline dna make different combinations
V,J,D
10
Single base substitution in the germline V gene segments can also generate different aa which are called blank
Somatic mutations
11
Any blank chain can combine with any blank chain
Light, heavy
12
Summary of AB diversity
Ok
13
B cells cannot change their own enzyme blank but can change their blank
Specificity, isotype
14
Isotype switching is blank because we can go from a long Ig to short Ig like IgM to IgD but not the other way around
Irreversible
15
Membrane bound Igs are mostly used as antigen blank on surface of cells
Receptors
16
Secreted and membrane bound Igs differ in blank terminus of the blank chain
C, heavy
17
R: a more chemically complex antigen is wanted because it can turn more things blank
On
18
R: heavy chains can be changed by these segments
J and D segments
19
Isotype switching is useful because different isotypes have different blank
Functions
20