Lec 4 - Generation Of Antibody Diversity Flashcards Preview

Dental Microbiology > Lec 4 - Generation Of Antibody Diversity > Flashcards

Flashcards in Lec 4 - Generation Of Antibody Diversity Deck (20):
1

Three levels of antibody diversity

Antibody binding, isotype switch, membrane interactions

2

Each b cell clones produces one unique set of blank and blank

Ig heavy chain, variable chain

3

Different portions of an immunoglobulin molecule are encoded by different genes and different combinations of these genes contribute to diversity

Alternative theory

4

Heavy and light chains are encoded by different blank

Genes

5

Different variable region genes are combined with different blank region genes

Constant

6

V regions are like interchangeable screwdriver blank

Tips

7

Additional short segment of dna which in b cells is joined to the V DNA between the C and V dna segments during gene rearrangement

J segments

8

This segment is involved in heavy chains gene rearrangement

D (diversity) segmnet

9

Different blank segments of germline dna make different combinations

V,J,D

10

Single base substitution in the germline V gene segments can also generate different aa which are called blank

Somatic mutations

11

Any blank chain can combine with any blank chain

Light, heavy

12

Summary of AB diversity

Ok

13

B cells cannot change their own enzyme blank but can change their blank

Specificity, isotype

14

Isotype switching is blank because we can go from a long Ig to short Ig like IgM to IgD but not the other way around

Irreversible

15

Membrane bound Igs are mostly used as antigen blank on surface of cells

Receptors

16

Secreted and membrane bound Igs differ in blank terminus of the blank chain

C, heavy

17

R: a more chemically complex antigen is wanted because it can turn more things blank

On

18

R: heavy chains can be changed by these segments

J and D segments

19

Isotype switching is useful because different isotypes have different blank

Functions

20

Everything in nature is made of repeating blank

Patterns