Lec 2-5 - Orthoinfluenza Flashcards Preview

Dental Microbiology > Lec 2-5 - Orthoinfluenza > Flashcards

Flashcards in Lec 2-5 - Orthoinfluenza Deck (22):
1

this has influenza viruses A & B

orthomyxoviruses

2

influenza serotypes that cause human illness

A/B

3

these are more ancient in humans and seem to have reached some equilibrium with us

B/C

4

influenza virus structure due to lipid bilayer not being rigid

pleomorphic

5

influenza virus has blank and blank peplomers

H, N

6

influenza A show a lot of variation in blank proteins but B and C do not

H, N

7

H is aka blank and is receptor binding protein for the virus and recognizes blank on the surface of a cell

hemagluttinin, sialic acid

8

N is aka blank and cleaves blank residues which is antagonistic to H... acts while the virus leaves the cell so it doesnt get stuck

neuraminidase, sialic acid

9

antigenic drift of influenza A is a blank change

minor (natural mutation)

10

antigenic shift is a blank change of influenza A

major (big change in the virus)

11

this often follows pulmonary influenza virus infection and has a bad prognosis

secondary bacterial pneumonia

12

fastest way to diagnose influenza virus

viral antigens

13

most sensitive way to diagnose influenza

PCR

14

lab diagnosis is by a blank fold rise in antibody titer

4

15

antiviral agents are active against blank via blank

both influenza A and B, neuraminidase inhibitors

16

these are active against influenza A ONLY

amantadine, rimantadine

17

anti neuraminidase agents work by blocking the site of blank but were not able to be metabolized by blank

sialic acid, neuraminidase

18

antibodies to HA stop blank

viral infection

19

antibodies to NA stop blank

replication/release

20

types of influenza vaccines

inactivated (TIV), live attenuated, recombinant HA

21

live attenuated vaccine is the same composition as TIV but composed of blank mutants

temperature sensitive

22

recombinant HA is good for those who have blank allergies

egg