Lec 12-2 - Immunodeficiency Flashcards Preview

Dental Microbiology > Lec 12-2 - Immunodeficiency > Flashcards

Flashcards in Lec 12-2 - Immunodeficiency Deck (22):
1

absence of thymus and cardiac abnormalities

digeorge syndrome

2

immunodificiency that interferes with stem cell development into neutrophil, monocyte, etc

primary

3

defective antibody response increases susceptibility to blank

pyogenic infections

4

defective cell mediated immunity increases susceptibility to blank

opportunistic infections

5

hereditary complement deficiencies lead to susceptibility to infections like this

neisseria

6

defects in phagocyte functions leads to defects in blank pathways

oxygen reduction

7

leukocyte adhesion deficiency would affect these

cell migration to infection sites

8

x linked scid most common type affects this

gamma chain of IL2

9

IL2 deficiency only causes a mild immunodeficiency but receptor KO has a severe phenotype because there are blank receptor subunits in the IL2 receptor family

shared

10

SCID X1 is the failure of these cells to develop

t, nk

11

deficiency of this molecule leads to defect of t cell signalizing

zap70

12

most common immunodeficiency

igA deficiency

13

igA deficiency is treated by these

replacing missing protein, replacing missing cell type, replacing missing or defective gene

14

nude mice are involved in cancer research and have a blank

vestigial thymus

15

major reservoir of hiv viral particles

lymphoid tissue

16

hiv infects cells that have these 2 receptors

ccr5, cxcr4

17

hiv causes progressive loss of these cells

cd4 helper t cells

18

evidence of infection with hive

seroconversion

19

these inhibit hiv infection by competing for coreceptors

chemokines

20

scid mice have an absence of blank b and t cells in secondary lymph organs

mature

21

genes that are mutated in scid mice that normal control vdj arrangement

rag1, rag2

22

hiv is hard to treat because it blank into the hosts genome and it blanks the immune system

integrates, evades