Lec 8-2 - Autoimmunity Flashcards Preview

Dental Microbiology > Lec 8-2 - Autoimmunity > Flashcards

Flashcards in Lec 8-2 - Autoimmunity Deck (24):
1

immunity to self

autoimmunity

2

two types of autimmunity

organ specific, systemic

3

thyroid self antigens are attacked and involves cd4 t cells and delayed type hypersensitivity

hashimoto's thyroiditis

4

auto antibodies to kidney and usually against type 4 collagen

goodpasteur's syndrome

5

auto antibodies to pancreatic beta cells in islets of langerhans

insulin dependent diabetes mellitus

6

progressive demyelination of nerves and is autoimmune

multiple sclerosis

7

diseases caused by antibodies have no blank but has altered function

no tissue destruction

8

hyperthyroid disorder that has antibodies against tsh receptor.... nervousness, weight loss, enlarged thyroid

grave's disease

9

grave's disease can present with blank

bug eyes

10

antibodies against ach receptor that has muscle weakening

myasthenia gravis

11

autoimmune disease of exocrine tissue that affects mostly women, dry mouth and eyes, crocodile skin

sjogren's syndrome

12

10 times more common in woemn, kidney dysfunction, rashes, weakness, fever, high complement, butterfly rash

systemic lupus erythematosis

13

chronic inflammation of joint that is more common in women and has antibodies to the fc region of igG

rheumatoid arthritis

14

treating ra is done by blank

blocking tnfalpha

15

defects in molecules that inactivate blank can cause autoimmunity

t cells

16

inhibitory receptor on t cells that downregulates t cell signaling response

ctla4

17

loss of blank cells and inhibitory cytokines may contribute to autoimmunity

T regs

18

b cell way of autoimmunity

failure of b cell tolerance

19

blank cells play a major role in downregulating autoimmunity

th17

20

genetic components to autoimmune diseases

mhc loci, hla

21

percentage of autoimmune diseases that occur in women

90

22

corticosteroids, cyclophosphamide are both blank

generalized immunosuppresants

23

targeted therapy that kills activated t cells only

cyclosporine a

24

women are more susceptible to autoimmune diseases because they are built to tolerate blank

foreign objects like babies