Lec 8 - Cytokines Flashcards Preview

Dental Microbiology > Lec 8 - Cytokines > Flashcards

Flashcards in Lec 8 - Cytokines Deck (31):
1

one cytokine acts on multiple cells and has multiple functions

pleiotropic

2

two cytokines have same function

redundant

3

sum is greater than parts

synergistic

4

one cytokine blocks function of another

antagonistic

5

ctyokines are generally not blank

stable

6

acts on the cell that secreted it

autocrine

7

acts on a nearby cell

paracrine

8

enters circulation and acts at distant site

endocrine

9

cytokiens are just really involved in blank of all different types of immunity and hematopoiesis

regulation

10

These cytokines are produced by mononuclear phagocytes, stimulate early responses to microbes. These are indicators of an inflammation.

regulate innate immunity

11

Produced by T cells during specific immune response. Regulate activation and differentiation of cells involved in T-dependent immune responses

regulate adaptive immunity

12

il2 regulates blank proliferation

t cell

13

il4 and ifn gamma regulates blank

isotype switching

14

Produced by bone marrow and thymic stroma, stimulate development of specific lineages of immune cells

regulate hematopoiesis

15

cytokine receptors are usually blank or blank

dimers, multimers

16

therapeutic approach to treat Rheumatoid Arthritis
Psoriasis

TNF inhibition

17

First found as growth factor for T cells, crucial step in allowing the study of T cells.
Plays a central role in T cell expansion and maintenance of T cell homeostasis
Critical for preventing autoimmunity

IL-2

18

IL-2Ralpha is the blank and is not required for signaling

affinity modulator

19

IL-2Rbeta is needed for blank

signaling

20

t cells that recognize antigen are stimulated by blank concentrations of IL-2

low

21

IL-2 kills blank t cells

activated

22

IL-2 blank the immune response

downregulates

23

without IL-2, we get severe blank diseases

autoimmune

24

This is considered to be the first, clear-cut example of successful gene therapy

gamma C

25

Most immune reactions are dominated by either populations and secrete different cytokines

Th1, Th2

26

develop when the activated T cell is exposed to IL-12 (usually from the APC, esp. dendritic cells)

Th1

27

develop when the activated T cell is exposed to IL-4 (from an unknown cellular source) (

Th2

28

Th 1 also increases cell mediated blank

cd8 killing

29

Th2 also increases the mediated blank

antibody killing

30

Secreted proteins that regulate cell movement and recruitment

chemokines

31

chemokines can be related in these

adhesion, shape changes, chemotaxis