Lec 7-2 - Allergy / Hypersensitivity Flashcards Preview

Dental Microbiology > Lec 7-2 - Allergy / Hypersensitivity > Flashcards

Flashcards in Lec 7-2 - Allergy / Hypersensitivity Deck (29):
1

process that occurs in subjects previously exposed to an antigen and who developed an immune response to that antigen

sensitization

2

type 1 hypersensitivity is blank mediated

igE

3

type 2 is blank mediated

ab mediated cytotoxicity, NK, complement... cell bound

4

type 3 is blank mediated

immune complex mediated (soluble)

5

type 4 is blank

cell mediated... no immunoglobulin

6

harmless antigens that can stimulate an igE response

allergens

7

upon first exposure to allergen, large amounts of blank are produced

igE

8

high affinity receptors for igE that bind ig# without the ig being bound to an antigen

FceRI

9

these bind free circulating igE via the FceRI

mast cells and basophils

10

this phase of allergic reaction is characterized by antigen binding and FceRI crosslinking

activation

11

upon activation, mast cells and basophils immediately go through blank

degranulation

12

contents of cellular granules are released into the surrounding environment

degranulation

13

in this phase, preformed mediators stored in cell granules are released

early phase

14

early phase response is responsible for the majority of severe clinical manifestations of blank

type 1 hypersensitivity

15

synthesis and secretion of cytokines and chemokines occurs in this phase

late phase

16

long lasting asthma that causes problems even in the absence of the original allergen

chronic asthma

17

systemic anaphylaxis can cause a loss of blank and blank collapse

blood pressure, cardiovascular

18

bee stings, peanuts, seafood, penicillin can all cause blank

systemic anaphylaxis

19

hay fever, atopic dermatitis, asthma can cause blank

localized anaphylaxis

20

many allergens cause igE production because they will be small and may have similar enzymes to blank which are what igE was made to respond to

parasites

21

two skin tests for allergies

prick test, intradermal test

22

allergic individuals have a higher level of blank igE and are more prone to blank cell stimulation

circulating, Th2

23

small amounts of allergen are given to switch response from igE to IgG

hyposensitization

24

transfusion reactions, hemolytic anemias, and antibodies are directed to tissue or cell surface antigens type of hypersensitivity

type 2

25

type 2 hypersensitivity is directed by these antibodies

igG, igM

26

in rhesus prophylaxis, anti rhD antibodies are given to the blank mother after delivering the blank baby

rh - , rh+

27

complement is triggered by igG and igM in this

type 3 hypersensitivity

28

type of sensitivity with cd4 and cd8 t cells involved

type 4 hypersensitivity

29

examples of type 4

contact dermatitis, tuberculin reactions