Lec 2-2 Control of the Immune Response Flashcards Preview

Dental Microbiology > Lec 2-2 Control of the Immune Response > Flashcards

Flashcards in Lec 2-2 Control of the Immune Response Deck (26):
1

5 mechanisms to regulate immunity

antigen blocking, receptor cross linking, passive regulation of ab affinity, immune complexes, idiotypic regulation

2

this is the competition for antigen with antigen receptors on b cells

antigen blocking

3

in antigen blocking, blank cover the antigen so the blank doesnt recognize it

antibodies, b cell

4

b cell differentiation is inhibited by blank antigen receptors with fc receptors on the b cells

cross linking

5

passive regulation for antibody affinity involve sequestering free antigen and only b cells with blank affinity receptors for the antigen will bind it

high

6

these are when the antigen and antibody are bound together

immune complex

7

immune complex cross linking augmentation occurs when blank crosslinks form between these receptors

fc receptors

8

inhibition occurs when blank receptors are crosslinked with blank

fc, antigen receptors

9

antigenic constitution of variable region of ig molecule

idiotype

10

antigenic determinants of which the idiotype is made up

idiotope

11

part of variable region which forms the antigen binding site

paratope

12

ab that recognizes idiotypic determinants of other ab... so abs become ags

antiidiotypic

13

antiidiotype abs that bind inside the ag combining site and will inhibit the ag from binding to that site

site associated antiidiotypes

14

antiidiotype abs that bind to antigenic determinants which are associated with the idiotype of an ig molecule but are not inside the ag combining site

non site associated antiidiotypes

15

antiidiotypic abs have their own blank so there are antibodies against them called blank

idiotypes, anti-anti-idiotypic antibodies

16

cells whose function is to regulate the immune system

regulatory t cells (suppressor t cells)

17

distinguishable characteristic of supressor t cells from helper/cytotoxic t cells

surface markers

18

proteins that remain in circulation, rather than those disposed of by the phagocytic system, tend to favor blank suppressor t cells

producing

19

conditions that favor suppressor t cells

type of ag, repeated administration of ag, route of ag administration, age of host

20

suppressor cells work by interacting with other cells, interacting with APCs, inhibiting secretion of blank, and suppressing idiotypic determinants

IL-2

21

t cell that becomes a major producer of cytokines

cd4

22

Il4 and interferon gamma inhibit development of blank cells

th17

23

response to antigen by a number of b cell clones that can be reacting via the same epitope or multiple epitopes

polyclonal response

24

costimulatory receptor on t cell that activates naive t cells

cd28

25

anti anti idiotypic regulated by anti anti anti....this is called the blank theory

network theory

26

network theory does/does not play a major role in antibody response

does not