Lec 11 Complement Flashcards Preview

Dental Microbiology > Lec 11 Complement > Flashcards

Flashcards in Lec 11 Complement Deck (39):
1

complements help blank with lysis of bacteria

antibody

2

these can by lysed

gram negative bacteria and rbc

3

gram positive cells are not lysed but they are blank

opsonized

4

complement leads to blank

inflammation

5

three complement pathways

classical, lectin, alternative

6

the only complement with the b getting ripped off because usually a gets ripped off

c2

7

a component with enzyme activity affecting the next piece

convertase

8

c3 convertase

c4bc2a

9

classical pathway involves these

c1,c4,c2

10

alternative pathway involves these

factor b, d, p

11

lectin pathway involves these

mbl, masp2, c4, c2

12

pathway that can work without an antibody

alternative, lectin

13

lectin pathway needs blank

sugar

14

c1q in classical pathway requires blank

calcium

15

convertase at the end of classical

c3

16

alternative pathway doesnt involve blank activation

antibody

17

stabilizer of alternative

properdin

18

end of alternative pathway

c3 convertase

19

adding c3b to c3 convertase creates blank

c5 convertase

20

lectin pathway is like classical pathway but instead of having c1q, there is blank

MBL and SF

21

MBL and SF blank just like c1q

require calcium

22

c5-c9 complex is aka blank

membrane attack complex

23

c5a, c3a, c4a are all blank

anaphylotoxins

24

c3b, c4b, iC3b, c1q are all blank molecules

opsonic

25

increase in c5-c9 causes blank

inflammation/coagulation

26

factor 1, c1 inhibitor, daf, cr1 are all blank

complement regulators

27

factor b and d blank alternative pathway

activate it

28

factor h and I blank alternative pathway

inhibit it

29

inhibitor of lectin pathway

c1INH

30

c1inh deficiency is important for dentists because it can cause severe blank

edema

31

measure the amount of each protein using traditional serologic assays

antigenic assay

32

lytic function of the components is measured

functional assay

33

functional assay or antigenic assay is better

functional

34

low complement levels may mean blank

autoimmunity/genetic deficiency

35

this complement deficiency affects all pathways

c3

36

alternative pathway deficiency

pus infection

37

paroxysmal nocturnal hemoblobinuria is deficiency in blank

daf

38

c1,c4, c2 deficiency increases risk of this

autoimmune ct disease

39

lectin pathway deficiency increases bacterial infections in blank

infants