Lec 4-2 - Mucosal Immunity

Question 1

most frequent portal of infection

Answer 1

mucosa

Question 2

tomasi showed that blank is the main ig in secretions

Answer 2

igA

Question 3

most lymphocytes are here

Answer 3

gi tract

Question 4

igA has a blank but not a blank

Answer 4

j chain, j segment

Question 5

igA downregulates production of these

Answer 5

igG, igM

Question 6

igA that is in serum and has a double y shape

Answer 6

sIga

Question 7

j chain is synthesized by blank

Answer 7

plasma cells

Question 8

ratio of j chain to ig polymer

Answer 8

1:1

Question 9

secretory component of igA is synthesized by blank cells not blank cells

Answer 9

epithelial, plasma

Question 10

secretory component of igA protects the ig from blank by intestinal enzymes

Answer 10

proteolysis

Question 11

most important function of sIgA

Answer 11

inhibit adherence/uptake at mucosae

Question 12

functional part of antibody

Answer 12

fc

Question 13

genitourinary, tracheobronchial trats, and intestines all have this

Answer 13

sIgA

Question 14

antigen transport and processing is done by this

Answer 14

MALT

Question 15

these overlay peyer’s patches and transport antigens to the macrophage or dendritic cells

Answer 15

microfold cells

Question 16

microfold cells lack blank molecules so they are not considered blank

Answer 16

mhc class 2, antigen presenting cells

Question 17

these are aka GALT and present antigens to lymphocytes

Answer 17

macrophage-like cells, dendritic cells

Question 18

iL5, IL4, 6,10,13 all promote blank synthesis

Answer 18

igA

Question 19

this increases igA secretion by b cells

Answer 19

tgfB1

Question 20

TGFB1 acts as an igA switch factor from blank to blank which decreases igG and igM secretion

Answer 20

igM, IgA

Question 21

cd20 is a marker for blank cells

Answer 21

b

Question 22

cd3 is a marker for blank cells

Answer 22

t

Question 23

b cell homing is independent of blank and appears to be blank

Answer 23

antigen, random

Question 24

secretory antibodies limit blank of protein antigens via mucosal membranes

Answer 24

absorption

Question 25

T cells presented with Ag peptides in the absence of co-stimulatory signals become refractory to further stimulation with Ag

Answer 25

anergy

Question 26

these cells actively suppress Ag-specific responses following re-challenge with Ag

Answer 26

regulatory t cells

Question 27

polio vaccine protects by blank at mucosa surfaces

Answer 27

sIgA

Question 28

mucosal vaccines prevent blank

Answer 28

entry of the pathogen

Question 29

difference between other immune responses and mucosal immunity is that the system gears itself into channeling a blank response

Answer 29

igA

Question 30

IgA is so important to the mucosa because it

Answer 30

prevents entry of pathogens

Question 31

helper t cells push igA response and downregulate these

Answer 31

igM, igG