Lec 4-2 - Mucosal Immunity Flashcards Preview

Dental Microbiology > Lec 4-2 - Mucosal Immunity > Flashcards

Flashcards in Lec 4-2 - Mucosal Immunity Deck (31):
1

most frequent portal of infection

mucosa

2

tomasi showed that blank is the main ig in secretions

igA

3

most lymphocytes are here

gi tract

4

igA has a blank but not a blank

j chain, j segment

5

igA downregulates production of these

igG, igM

6

igA that is in serum and has a double y shape

sIga

7

j chain is synthesized by blank

plasma cells

8

ratio of j chain to ig polymer

1:1

9

secretory component of igA is synthesized by blank cells not blank cells

epithelial, plasma

10

secretory component of igA protects the ig from blank by intestinal enzymes

proteolysis

11

most important function of sIgA

inhibit adherence/uptake at mucosae

12

functional part of antibody

fc

13

genitourinary, tracheobronchial trats, and intestines all have this

sIgA

14

antigen transport and processing is done by this

MALT

15

these overlay peyer's patches and transport antigens to the macrophage or dendritic cells

microfold cells

16

microfold cells lack blank molecules so they are not considered blank

mhc class 2, antigen presenting cells

17

these are aka GALT and present antigens to lymphocytes

macrophage-like cells, dendritic cells

18

iL5, IL4, 6,10,13 all promote blank synthesis

igA

19

this increases igA secretion by b cells

tgfB1

20

TGFB1 acts as an igA switch factor from blank to blank which decreases igG and igM secretion

igM, IgA

21

cd20 is a marker for blank cells

b

22

cd3 is a marker for blank cells

t

23

b cell homing is independent of blank and appears to be blank

antigen, random

24

secretory antibodies limit blank of protein antigens via mucosal membranes

absorption

25

T cells presented with Ag peptides in the absence of co-stimulatory signals become refractory to further stimulation with Ag

anergy

26

these cells actively suppress Ag-specific responses following re-challenge with Ag

regulatory t cells

27

polio vaccine protects by blank at mucosa surfaces

sIgA

28

mucosal vaccines prevent blank

entry of the pathogen

29

difference between other immune responses and mucosal immunity is that the system gears itself into channeling a blank response

igA

30

IgA is so important to the mucosa because it

prevents entry of pathogens

31

helper t cells push igA response and downregulate these

igM, igG