Flashcards in Lec 3-2 Self Recognition Deck (20):
1
state of unresponsiveness specific for a particular antigen
tolerance
2
immune system still blank that it is tolerant to, it just doesnt blank
recognizes, react
3
we are not conceived knowing black vs blank
self vs non self
4
immunological self covers all blank encoded by an individuals dna
epitopes
5
relating to lymphocytes and epitope... time, site, nature, production are all factors for blank
induction
6
route to tolerance that is the physical deletion of lymphocytes from the peripheral repertoire
clonal deletion
7
route to tolerance that is the prevention of further differentiation of immature cells (these escaped deletion)
clonal abortion
8
downregulation of mechanisms of immunological response
clonal anergy
9
route to tolerance that are interactions with other cells and or inhibitory factors
continuous inhibition
10
two induction mechanisms of t cell tolerance
positive, negative
11
t cells that are selected because they can bind to mhc molecules
positive selection
12
t cells that are selected like undercover cops because they bind to mhc but are reactive to self antigens
negative selection
13
specialized cd8 cells that bear self epitopes and impart a negative signal to kill self reactive clone
veto cells
14
if an antigen gets past the thymus then it may not provoke a response... this is called blank even though it isnt technically a "tolerance"
post thymic tolerance
15
lack of self reactivity by B cells is probably due to lack of blank but blank
t cell help, not always
16
tolerance must be imposed on b cells during blank AND after blank
development, antigenic stimulation in secondary lymphoid tissues
17
membrane self antigens can crosslink ig receptors on b cells and these cells are eliminated from lymphoid tissues
clonal deletion
18
monomeric soluble self antigens do not cross link ig receptors so they are not eliminated from lymphoid tissues but they are rendered anergic in blank
clonal anergy
19
clonal anergy occurs when antigen is above blank
critical threshold
20