Lec 3-2 Self Recognition Flashcards Preview

Dental Microbiology > Lec 3-2 Self Recognition > Flashcards

Flashcards in Lec 3-2 Self Recognition Deck (20):
1

state of unresponsiveness specific for a particular antigen

tolerance

2

immune system still blank that it is tolerant to, it just doesnt blank

recognizes, react

3

we are not conceived knowing black vs blank

self vs non self

4

immunological self covers all blank encoded by an individuals dna

epitopes

5

relating to lymphocytes and epitope... time, site, nature, production are all factors for blank

induction

6

route to tolerance that is the physical deletion of lymphocytes from the peripheral repertoire

clonal deletion

7

route to tolerance that is the prevention of further differentiation of immature cells (these escaped deletion)

clonal abortion

8

downregulation of mechanisms of immunological response

clonal anergy

9

route to tolerance that are interactions with other cells and or inhibitory factors

continuous inhibition

10

two induction mechanisms of t cell tolerance

positive, negative

11

t cells that are selected because they can bind to mhc molecules

positive selection

12

t cells that are selected like undercover cops because they bind to mhc but are reactive to self antigens

negative selection

13

specialized cd8 cells that bear self epitopes and impart a negative signal to kill self reactive clone

veto cells

14

if an antigen gets past the thymus then it may not provoke a response... this is called blank even though it isnt technically a "tolerance"

post thymic tolerance

15

lack of self reactivity by B cells is probably due to lack of blank but blank

t cell help, not always

16

tolerance must be imposed on b cells during blank AND after blank

development, antigenic stimulation in secondary lymphoid tissues

17

membrane self antigens can crosslink ig receptors on b cells and these cells are eliminated from lymphoid tissues

clonal deletion

18

monomeric soluble self antigens do not cross link ig receptors so they are not eliminated from lymphoid tissues but they are rendered anergic in blank

clonal anergy

19

clonal anergy occurs when antigen is above blank

critical threshold

20

anergy is associated with the blank receptor

IgM