Lec 3-2 Self Recognition

Question 1

state of unresponsiveness specific for a particular antigen

Answer 1

tolerance

Question 2

immune system still blank that it is tolerant to, it just doesnt blank

Answer 2

recognizes, react

Question 3

we are not conceived knowing black vs blank

Answer 3

self vs non self

Question 4

immunological self covers all blank encoded by an individuals dna

Answer 4

epitopes

Question 5

relating to lymphocytes and epitope… time, site, nature, production are all factors for blank

Answer 5

induction

Question 6

route to tolerance that is the physical deletion of lymphocytes from the peripheral repertoire

Answer 6

clonal deletion

Question 7

route to tolerance that is the prevention of further differentiation of immature cells (these escaped deletion)

Answer 7

clonal abortion

Question 8

downregulation of mechanisms of immunological response

Answer 8

clonal anergy

Question 9

route to tolerance that are interactions with other cells and or inhibitory factors

Answer 9

continuous inhibition

Question 10

two induction mechanisms of t cell tolerance

Answer 10

positive, negative

Question 11

t cells that are selected because they can bind to mhc molecules

Answer 11

positive selection

Question 12

t cells that are selected like undercover cops because they bind to mhc but are reactive to self antigens

Answer 12

negative selection

Question 13

specialized cd8 cells that bear self epitopes and impart a negative signal to kill self reactive clone

Answer 13

veto cells

Question 14

if an antigen gets past the thymus then it may not provoke a response… this is called blank even though it isnt technically a “tolerance”

Answer 14

post thymic tolerance

Question 15

lack of self reactivity by B cells is probably due to lack of blank but blank

Answer 15

t cell help, not always

Question 16

tolerance must be imposed on b cells during blank AND after blank

Answer 16

development, antigenic stimulation in secondary lymphoid tissues

Question 17

membrane self antigens can crosslink ig receptors on b cells and these cells are eliminated from lymphoid tissues

Answer 17

clonal deletion

Question 18

monomeric soluble self antigens do not cross link ig receptors so they are not eliminated from lymphoid tissues but they are rendered anergic in blank

Answer 18

clonal anergy

Question 19

clonal anergy occurs when antigen is above blank

Answer 19

critical threshold

Question 20

anergy is associated with the blank receptor

Answer 20

IgM