Lec 6-4 - Mycobacteria/Nocardia Flashcards Preview

Dental Microbiology > Lec 6-4 - Mycobacteria/Nocardia > Flashcards

Flashcards in Lec 6-4 - Mycobacteria/Nocardia Deck (26):
1

look at old questions

ok

2

long chain fatty acids and is much of organisms genetic info for synthesis and substitution of these lipids

mycolic acids

3

Mycobacterium tuberculosis replicates blank compared to other clinically important bacteria

slowly

4

generation time for tuberculosis

15-20 hours

5

stain for tuberculosis

ziehl nielson

6

organism resists decolorization by blank so it is considered acid fast

acid alcohol

7

shape of tuberculosis

bacillus

8

mycolic acid is in this part of a cell and the chains are longer in tuberculosis than nocarda/corynebacteria

cell wall

9

special media for growing mycobacteria but growing is slow

lowenstein jensen agar

10

ppd stands for

purified protein derivative test

11

people infected with tuberculosis but dont have the disease cannot blank

spread the infection (called latent tb infection)

12

it may take this many weeks for the infected person to develop a positive reaction to the test

2-10 weeks

13

percent of people infected with tb will develop the disease within the first 1-2 years after infection

5 %

14

percent of people that will develop tb disease after infection sometime after those 2 years

5% (10% total)

15

the latent tb infection is proven with the blank

chest x ray

16

enzyme product of the gene katG in isoniazid. if mycobacterium doesnt have this enzyme then it will be resistant to isoniazid

catalase/peroxidase

17

chemotherapy of tb

isoniazid... sometimes rifampin

18

isoniazid mechanism of action

inhibit synthesis of mycolic acid in cell wall

19

two things that can be affected by isoniazid

liver (hepatitis), neurotoxicity (dont drink alcohol)

20

rifampin mechanism of action

inhibit dna dependent rnap of mycobacterial cells

21

cause of leprosy

mycobacteria leprae

22

leprosy has skin lesions, hypoesthesia and blank

peripheral neuropathy

23

risk of nocardia is associated with deficient blank immunity

cell mediated (aids, lymphoma, transplantation)

24

most common problem with nocardia

respiratory diseases like cough, fever

25

nocardia is diagnosed by branching blank that is acid fast on a modified acid fast stain because there is like half the amount of mycolic acid

branching gram positive hyphae

26

nocardia is treated by blank

sulfonamides