Lec 5 Major Histocompatibility Complex Flashcards Preview

Dental Microbiology > Lec 5 Major Histocompatibility Complex > Flashcards

Flashcards in Lec 5 Major Histocompatibility Complex Deck (28):
1

major histocompatibility complex is a region formed by genetic loci involved in blank

foreign tissue rejection

2

mhc is central role in blank and blank immunity

cell mediated, humoral

3

mhc class that binds endogenous Ag expressed on all nucleated cells

class 1

4

mhc class that binds exogenous antigen. these molecules are only on antigen presenting cells

class 2

5

mhc class that has soluble serum proteins

class 3

6

mhc is involved in determining if we can take a blank

transplant

7

mhc are highly blank which that there are many alternate forms of the gene which means it is difficult to find a match for things like a bone marrow transplant

polymorphic

8

functional assay class of mhc mapping that is cell mediated lympholysis and complement mediated cytotoxicity

class 1

9

functional assay class that is mixed lymphocyte reaction

class 2

10

mhc class that has alpha and beta 2 microglobulin that looks like it is standing on one leg

class 1

11

mhc class 1 is found on membranes of all blank cells

nucleated

12

mhc class that is 2 polypeptide chains and both alpha and beta chain go through the membrane

class 2

13

mhc class 2 is found on certain blank cells

immune/antigen presenting

14

mhc class 3 are blank proteins and play blank role in antigen presentation

soluble, no

15

mhc diversity is greater than blank

1 trillion

16

both class 1 and 2 mhc are synthesized here

RER

17

class 1 mhc has binding of antigen occurring in the blank

rer

18

class 2 mhc has binding of antigen occuring in the blank

lysosome

19

differences between immunoglobulins and t cell receptors

t cell receptors are never secreted and only exist on surface, no somatic mutation

20

most t cell receptors are blank

alpha beta

21

these t cell receptors are peripheral blood cells

gamma, delta

22

v and j variable regions are blank

alpha

23

vjd variable regions are blank

beta

24

t cell selection that is a self antigen and mhc reactive cells are induced to die

negative selection

25

t cell selection that is when t cells with tcr that can easily interact with one or more self mhc moleucles are allowed to mature

positive selection

26

all mature b cells express blank and blank

igM, igD

27

b cells lose surface ig when they become blank

plasma cells

28

antigen binding to mIg alone is not sufficient to induce blank proliferation

b cell