Lec 6-2 Tumor Immunology and Immunotherapy Flashcards Preview

Dental Microbiology > Lec 6-2 Tumor Immunology and Immunotherapy > Flashcards

Flashcards in Lec 6-2 Tumor Immunology and Immunotherapy Deck (28):
1

epithelial tissue tumor

carcinoma

2

ct tumor

sarcoma

3

wbc tumor

leukemia, lymphoma, myeloma

4

recurring tumors... antigens that were originally lost after embryo to adult development

oncofetal antigens

5

tumor looks like tissue

differentiated

6

tumor that doesnt look much like tissue

undifferentiated

7

grade of cancer that is undifferentiated and therefore the worst

grade 4

8

induced b cell lymphomas developed from taking immunosuppressents

epstein barr virus - burkitt lymphoma

9

most human tumors are not blank

viral

10

how a tumor can change its immunogenicity throughout its growth

immunoediting

11

a checkpoint molecule that is a negative regulator of t cell proliferation

ctla-4

12

immune surveillance is done by blank which kills tumors if they find them

t cells

13

this will often prevent a tumor from being found by immune surveillance

immunoediting

14

direct killing of tumor specific t cells is done by these cells

cd4, cd8

15

component of class 1 molecule on all nucleated cells

beta 2 microglobulin

16

afp is a tumor marker involved in staging these cancers

hepatoma, testicular

17

afp l3 differntiates benign from malignant blank

liver cancer

18

marker in breast cancer

ca 15-3 and ca 27-29

19

marker for monitoryign pancreatic and bile duct cancers

ca 19-9

20

marker for ovarian cancer

ca 125

21

antigen used for staging... high at diagnosis means bad outlook

CEA

22

antigen to id prostate cancer

PSA

23

chemokines that attract Tregs in tumor progression

CCL22

24

Tregs are good or bad for cancer

bad... means worse cancer

25

variable heavy and light chain region that is distinguishing of a b cell

idiotype

26

chimeric antigen receptor - t cell is made up of these

cd 3, and variable heavy and light chains of the antibodies

27

chimeric antigen receptor t cell is advantageous because it is not blank

not toxic

28

chimeric antigen receptor t cell cons

infections, more cancer... because t cells are pretty much shut down