Joints are made up of what 4 things?
water
collagen
non-collagenous matrix
chondrocytes
Which part of cartilage is 75% of the mass?
water
Which part of cartilage is 15-22% of the mass?
collagen
Which type of collagen is used in cartilage?
type 2
Which part of cartilage is 4-7% of the mass?
non-collagenous matrix
_______ is responsible for the synthesis of matrix
chondrocytes
Cartilage is __________ and lacks __________
avascular
neurons
Cartilage damage is not painful. What part of joint injury is actually painful?
“joint capsule” or damage-induced synovitis
The ambient environment of chondrocytes is ______ and ________. Why?
hypoxic
acidotic
keeps chondrocytes from becoming osteocytes (elastic -> bone NO BUENO)
What’s the main difference between how cartilage and bone interact to forces?
cartilage withstands compression AND shear, bone just compression
What causes joint resistance to shear?
parallel fibers on joint surface
Non-collagenous matrix has “ground substance”, which looks ________ and retains _____
granular
stain
Non-collagenous matrix contains _____ ________ and ________
hyaluronic acid
aggrecan
non-collagenous matrix has a _____-_________ arrangement
bottle-brush
Non-collagenous matrix has ______ and _______, which cause strong attraction to each other
carboxyls
disulfides
The purpose of joints it to support _____ and provide _______, _______ movement
weight
selective
directional
Joints provide movement based on _____ and ____ of joint
location
shape
What are the 3 biomechanical properties of joints?
1) resist compression
2) resist tension
3) resist torsion
Joints resist compression through _______ and ______
matrix
water
Joints resist tension through ______ _______ and ______ What else do these 2 things resist?
joint capsules
ligaments
torsion
Joints use their _______ and ______ to resist torsion (design)
grooves
ridges
Which biomechanical force do we want MINIMAL resistance to in joints?
shear
What helps keep minimal resistance to shear in joints?
water (lubrication)
Water is considered _______ and should prevent cartilage from touching other cartilage
noncompressive