NW and OW NHP models Flashcards Preview

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Flashcards in NW and OW NHP models Deck (209)
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31

chracteristics of model for Chron's disease

spontaneous terminal ileitis resembling Chron's disease in humans has been reported. etiology unknown, primary lesion is ulceration and thickening of the terminal portion of the ileum

32

animal model for Atherosclerosis

Cebus spp, Saimiri sciureus, addition of cholesterol to the diet results in hypercholesterolemia and exacerbation of atherosclerosis

Macaca mulatta, fascicularis, Chlorocebus aethiops, Papio spp

 

33

characteristics of spontaneous model for atherosclerosis

can study plaque regression and atherogenesis studies, and also effects of multiple risk factors suck as diet, stress, hormones, pharmacologic agents, and psychosocial factors

34

animal model for hypertension

Aotus nancymae, Lagothrix lagotricha

 

 

35

characteristics of model for hypertension

spontaneous, neural based, hyperactive responses of the sympathetic nervous system

36

animal model for infantile strabisus

Saimiri spp

 

Macaca nemestrina, fascicularis,

Papio cynocephalus

37

characteristics of model for strabismus

esotropia in newborm monkeys by surgical tenotomy of both lateral rectus muscles

or injection of Botulinum A neurotoxin (reversible, can study recovery)

 

38

animal model for retinal ganglion cell morphology

Callithrix jacchus

39

characteristics of model for retinal ganglion cell morphology

good visual acuity and its retinal and subcortical pathways are very similar to humans

40

animal model for retinal degeneration

Saimiri spp

41

characteristics of model of retinal degeneration

spontaneous retinal degeneration similar to human degenerative disorder

42

animal model for retinal detachment

Aotus spp

43

characteristics of model for retinal detachment

correlations of naturally occurring detachments with long-term retinal detachment in owl monkeys

44

animal model for myopia

Callithrix jaccus

Macaca mulatta, arctoides  (cats, tree shrews, marmosets, guinea pigs, and chickens)

 

45

characteristics of model for myopia

induced in infant animals, eyelids are surgically fused at birth and kept closed for one year

46

animal model for motion sickness

Saimiri spp

47

characteristics of model for motion sickness

induces by vertical oscillation and horizontal rotation, squirrel monkeys will vomit and are more active during test than most other NHPs

48

uses of model of motion sickenss

testing anit-motion sickness preparations

49

animal model of lymphocytic thyroiditis

Callithrix jacchus

50

characteristic of model of lymphocytic thyroiditis

chronic lymphyocytic auto-immune thyroiditis in conjunction with circulating antibodies to thyroid antigen, marmoset lesions are comparable to humans, marmosets show same sex predilection as seen in humans

51

animal model for stress

Saimiri, Callithrix

52

characteristics of model for stress

total circulating cortisol is 10 times greater than in humans, thought to be due to the disruptive presence of immature offspring that produces a chronic cortisol increase in captive adult squirrel monkeys

53

animal model for erythroblastosis fetalis

marmosets Callithrix spp

54

animal model for IgE studies

Callithrix jacchus

55

characteristics of erythroblastosis fetalis

similar fetoplacental situation, knowledge of blood groups

56

animal model for toxoplasmosis

Lagothrix lagothricha, Aotus lemurinus

57

characteristics of toxoplasmosis in NHP model

acute spontaneous, more frequent in NW than OW, a single case report in a male woolly monkey, source eating raw meat

58

animal model of malaria

Aotus spp, Saimri spp

 

Chipmanzee, Macaca mulatta

59

species of Malaria causing disease in man

Plasmodia falciparum, malariae, vivax, ovale

60

characteristics of malaria model

Aotus are susceptible to P. vivax, malaria is host specific, , S boliviensis are susceptible to infection with P. falciparum and different strains of P. vivax

Chimpanzees are the only known host for P. ovale

M.mulatta can be infected with a virulent strain of P. knowlesi