NW and OW NHP models Flashcards Preview

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Flashcards in NW and OW NHP models Deck (209)
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61

what species does the world health organization recommend as a model for evaluation of malaria vaccine candidates

Aotus nancymae

62

animal model for Haemobartonellosis

Saimri spp

63

characteristics of model for Haemobartonellosis

patent infection occurs following splenectomy, carriers commin in colony reared squirrel monkeys. reason for treating splenectomized squirrel monkeys with oxytetracycine before use in malaria studies.

64

animal model for Chaga's Disease

Cebus paella, chronic chagasic cardiomyopathy

65

characteristics for model of Chaga's Disease

cardiac lesions, focal or multifocal mononuclear infiltrates and/or isolated fibrosis

66

animal model for Cutaneous and Visceral Leishmaniasis

Aotus spp, Saguinus geoffroyi

visceral leshmaniasis- Chlorocebus aethiops

(hamsters are original animal model)

67

characteristics of model for Leishmaniasis

NHP develop self-limiting skin lesions with L. braxiliensis complex and severe to fatal visceral disease with L. donovani. transmitted by sandflies

68

animal model for Lymphocytic Choriomeningitis Virus Infection

Cebus albifrons

 

also: Macaca mulatta and fascicularis

69

characteristics of LCMV model

most common syndrome is meningitis nearly all LCM patients recover

70

animal model for yellow fever

Marmosets, tamarins, owl, spider, and squirrel monkeys, rhesus

 

71

characteristics of model of yellow fever

pathological species seen in NHP is similar to those in man

 

M. mulatta= disease resembles hyperacute form seen in man

NW are all extremely susceptible, except Cebus which are usually asymptomatic and Ateles are resistant

72

animal model for Dengue fever

Aotus nancymae

73

characteristics of Dengue fever model

Aotus develops viremia but no Dengue fever, or Dengue shock syndrome like humans

74

animal model of Eastern Equine Encephalitis

Aotus nancymae

75

characteristics of EEE model

A. nancymae sustains short term viremia and produces IgM and IgG post EEEV infection but no clinical disease, non-lethal model for evaluation of candidate vaccines against EEEV

76

animal model of Argentinian Hemorrhagic Fever

Callithrix jacchus

77

characteristics of Argentinian Hemorrhagic Fever

experimentally induced disease is quite similar to the natural infection of man

78

animal model of measles

Saimiri sciureus, Saguinus mystax

Masaca fascicularis

 

79

characteristics of model of measles

severe disease when introduced to captive NW monkey, typically see GI effects such as necrotizing colitis

80

animal model for human T-cell Lymphotropic virus (non-hodgkin's lymphoma)

squirrel monkeys

Papio sp

81

characteristics of HTLV

chronically infected monkeys developed high titers of antibodies against structural proteins of the virus, as do HTLV humans, squirrel monkeys may be useful to study the pathogenesis of HTLV and for evaluating new candidate vaccines

HTLV is similar to STLV-1

82

animal model for Epstein-Barr Virus

Callithrix jacchus

Macaca mulatta

83

characteristics of EBV model

the B95-9 strain of EBV induces malignant lymphomas in cotton top tamarins, used to evaluate EBV vaccines

 

in Macaques develop key aspects of human infection

84

animal model fro Klebsiella pneumonia

SQuirrel monkey, marmosets

85

characteristics for Klebsiella

lobar pneumonia develops after administration of only 700 organisms

86

animal model for Helicobacter pylori infection

Saimiri spp

87

characteristics of Helicobacter infection model

experimentally induced infection in Saimiri, used in immunogenicity and safety studies

88

which hepatitis viruses are enterically transmitted?

A and E

89

which hepatitis viruses are parenterally transmitted?

B,C, delta

90

which hepatitis viruses produce disease in both OW and NW primates

A and E