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Flashcards in NW and OW NHP models Deck (209)
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151

characteristics of hydronephrosis of pregnancy

incidence same in man and monkey, right ureter most often affected, caused by obstruction of ureter by gravid uterus.

152

animal model of carcinoma of the urinary bladder

Cebus apella

153

characteristics of carcinoma of the urinary bladder model

inflammatory response to schistosome eggs produce acute and chronic cystitis and uteritis, develop multifocal urethelial lesions that tend to regress as the infection become less active and changes are more hyperplastic rather than neoplastic

154

animal model of Burkitts lymphoma

Saguinus oedipus, Aotus, Ateles geoffroyi

155

characteristics of Burkitt's lymphoma

herpesvirus saimiri and ateles isolated from apparently healthy squirrel and spider monkeys respectively. H. saimiri in tamarins, spider monkeys and owls produces malignant lymphoma with leukemia. H. ateles can induce in S. oedipus

156

animal model for hemolytic anemia of premature infants

Cebus albifrons, apella

157

characteristics of hemolytic anemia of premature infants

induced in young growing animals fed diets high in polyunsaturated fats, NW are more susceptible

158

animal model for folate deficiency, megaloblastic anemia

Cebus albifrons

159

characteristics of folate deficiency diet

three year old Cebus albirfons were fed a folate deficient diet and developed same stage of disease that humans did

160

Cercocebus atys are a model for?

AIDS/SIV/ leprosy

161

Chlorocebus spp are a model for?

Yellow fever, plague, leprosy, Hepatitis, Legionnaires' Disease, varicella, atherosclerosis

162

Erythrocebus patas are a model for?

pregnancy toxemia, Varicella infection

163

Chimpanzees are a model for?

AIDS, Hepatitis A,B, C,E, vaccine development and final safety testing, congnition and language development

164

animal models for HIV

Macaca arctoides, cyclopis, fascicularis, mulatta, nemestrina, Pan troglodytes, Papio spp

165

characteristics of HIV infection in macaques

cannot be infected with HIV-1. Pig tailed macaques can be infected but fail to develop disease. HIV2 (more similar to SIV) can infect pig-tailed macaques and baboons

166

characteristics of SIV infection

outside their normal host range, especially in macaques, these viruses cause an AIDS like disese similar to that of HIV infected patients

167

natural hosts for SIV infection

African green monkeys, sooty mangaby

168

animal model for cardiopulmonary disease/ pulmonary hypertension, cor pulmonale and endocardial fibroelastosis

Macacca arctoides

169

characteristics of induced model of pulmonary hypertension

2% monocrotaline solution injected SQ in infant M. arctoides

170

animal model for macular cyst

Macaca fascicularis

171

induction of animal model for macular cyst

injec Perfluoropropane (C3F8) into the eye, develop in about 3 months after injection

172

animal model for diabetes mellitus 

Macaca nigra is classic

173

ABO blood group antigens are present on which cell types

endothelial cells, exocrine secreations, primary sensory neurons,

 

NOT ERYTHROCYTES, use saliva for typing not blood

174

animal model for varicella infection

Erythrocebus patas

Chlorocebus aethiops

175

life cycle of malaria

sporozoite penetrates and goes to hepatocyte to become trophozoite matures to Schizont, differentiates into merozoite that invades RBS's

176

animal modesl for leprosy

Cercocebus torquatus atys

Pan troglodytes

Chlorocebus aethiops

Macaca mulatta

177

animal model for Tuberculosis

Macaca fascicularis

178

characteristics of animal model for TB

Macaca fascicularis is the first good model for chronic TB in humans, develop pulmonary disease in people with progression to clinical syndromes

179

animal model for male pattern baldness

Macaca arctoides

180

animal model for nonalcholic fattly liver disease

Macaca radiata