NW and OW NHP models Flashcards Preview

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Flashcards in NW and OW NHP models Deck (209)
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181

animal model for meningoencephalocele

MAcaca mulatta

182

183

184

animal model for saccular cerebral aneurysms

NHPs in general

185

creation of induced animal model for saccular cerebral aneurysms

ligation of one common carotid artery, production of experimental hypertension and feeding of A-aminopropionitrile

186

animal model for hydrocephalus

Macaca mulatta

187

creation of induced animal model of congenital hydrocephalus

intracerebral inoculation with an attenuated influenza A vaccine cirus in fetal monkeys

188

animal model for huntington's disease

Macaca fascicularis

Papio sp

189

creation of induced model of Huntington's disease

 chronic administration of 3NP

injections of quinolinic acid into the striatum

190

animal model of toxemia of pregnancy

Erythrocebus patas

191

characteristics of spontaneous model of Toxemia of Pregnancy

abrupt onset between day 7 prepartum and the day of parturition

does not progress beyond preeclamptic stage

192

animal model for preeclampsia

Macaca mulatta

193

induction of model for preeclampsia

chronic constriction of the lower aorta

194

animal model for gonorrhea

Pan troglodytes

195

characteristics of model of Gonorrhea

Chimpanzee is unique in its susceptibility to mucosal surface infection, can study pathogenesis, mechanisms of host response, treatments, and vaccines

196

animal model for endometriosis

Macaca mulatta

197

Animal model for resentosis

Cynomologys monkeys

198

characteristics of model for restenosis

fed an atherogenic diet for 3 months

angioplasty performed

response to angioplasty appears to closely resemble that in humans

199

animal model for scrub typhus

Macaca fascicularis

Presbytis cristatus

200

characteristics of Scrub typhus model

Rickettsia tsutsugamushi

cynos develop same clinical response as humans

201

animal model for lymp neuroborreliosis

Macaca mulatta

202

characteristics of model for Lyme Neuroborreliosis

Lyme= Borelia burgdorferi, 

macaques demonstrate many of the clinical and pathological features of the disease in humans including cutaneous rash, myocarditis, CSF pleocytosis, and CNS meningitis

203

animal model for cytomegalovirus

Macaca mulatta

 

204

characteristics of model of cytomegalovirus

infection of Rhesus with rhesus cytomegalovirus is model for human cytomegalovirus infection

lessons learned from RhCMV should have direct clinical relevance to HCMV and the design of protective vaccines

205

animal model of alzheimer's disease

aged Macaca mullata

206

characteristics of model for alzheimer's disease

have progressive cerebral deposition of the amyloid beta-protein

207

animal model for Experimental Allergic Encephalomyelitis

Macaca mulatta

Macaca fascicularis

marmosets

208

creation of animal model for Experimental Allergic Encephalomyelitis

intradermal injection of homologous myelin basic protein in CFA

 

causes a delayed type hypersensitivity reation to host myelin, leads to fatal demyelinating, necrotizing inflammation in the brain and spinal cord

209