Flashcards in Occ Health Guidelines Deck (123)
Ultrasonography is not covered by the OSHA noise standards. T/F
False, if frequency is less than 20 kHz, it is covered
Employee knowledge of chemical hazards and protective measures has been increased due to what 2 OSHA health and safety standards?
hazard communication standard, occupational exposure to hazardous chemical in laboratories
Name some hazardous properties of chemicals
flammability, corrosiveness, reactivity, explosivity, toxicity
what are the most common chemical injuries associated with animal care and use?
burns and irritation of the skin, allergic response in sensitized people
Hazards associated with experimental protocols are influenced by what 2 principal factors?
dangerous qualities of the experimental agents
complexity or type of experimental operations
What are the recommended sequences of stages that sould be considered in planning a safe experiment
evaluating hazards and assessing risks
management of chemicals
working with chemiclas
working with equipment
disposal of chemicals
government regulations of lab
Transmission of zoonotic disease in an animal facility that is not involved with infectious disease is rare. T/F
What does SALS stand for?
Subcommittee on Arbovirus Laboratory Safety
What factors go into the selection of an appropriate biosafety level? Specifically, what characteristics of the infectious agent?
severity of disease, mode of transmission, availability of protective immunization or effective therapy, relative risk of exposure created by manipulation in handling the agent and caring for infected animals
List and describe animal biosafety levels
ABSL1: basic level of protection for well characterized agents not known to cause disease in healthy humans
ABSL2: handles broad spectrum of moderate risk agents that cause disease in humans by ingestion, percutaneous or mucous membrane exposure
ABSL3: Agents that present risk of respiratory transmission, can cause serious and potentially lethal infection
ABSL4: Exotic agents posing high individual risk of life threatening disease by aerosol route and for which no treatment is available
What estimated % of all lab workers eventually develop occupational related asthma?
Allergy is most often manifested by cough, wheezing, and shortness of breath when exposed to lab animals. T/F
False, most often manifested by nasal symptoms, itchy eyes and rashes
List risk groups for workers exposed to lab animals based on history of allergic disease and sensitization to animal proteins
Normal- no evidence of allergic disease
Atopic- pre existing allergic disease
Asymptomatic- IgE abs to allergenic animal proteins
Symptomatic- Clinical symptoms on exposure to allergenic animal proteins
In almost all asthmatic people with lab animal allergy, and shortness of breath when exposed to lab animals. T/F
Which of the following are examples of anaphylactic reactions?
a. diffuse itching, hives, swelling of face, lips, tongue
b. difficulty breathing due to laryngeal edema
c. asthma with wheezing
d. loss of consciousness due to shock
f. all of the above
allergic reactions are mediated by what class of immunoglobulins?
What is the most common route of exposure in lab animal allergy?
Mast cells are most abundant in what sites?
Respiratory tract, GI tract, Skin
An autosomal dominant trait with variable expression linked to genetic markerson Ch5 has been linked to people more likely to develop IgE abs to allergins
List types of allergic reactions to lab animal allergens
Contact urticarial, allergic conjunctivitis, allergic rhinitis, asthma, anapylaxis
What are the major sources of rat allergen exposure?
urine and saliva
Name a major rat urine allergen.
Name a major mouse allergen
Urine samples from mice contain 100x more Mus m 1 than males. T/F
Female mice excrete 4x more Mus m than males. T/F
What are the sources of allergens from guinea pigs? What is the major source?
Dander, fur, saliva, urine. Urine=major
Sources of allergens from rabbits? Which are major and which are minor?
Major glycoprotein allergen in fur. Minor allergenic components in saliva and urine.
Allergy to cats might predispose workers to the development of allergy to lab animals. T/F
Name the major cat allergen. Where is it produced?
Protein Fel d1. produced in sebaceous glands of skin and saliva