Pharmacology Flashcards
(111 cards)
1
Q
Four categories of small molecules
A
Acetylcholine (ACh), monoamines, amino acids, and ATP and its byproducts
2
Q
What molecule does adenosine work with?
A
Caffeine
3
Q
Where is serotonin released?
A
Pons, particularly the raphe nuclei which often works with the locus coeruleus, projecting widely to the brain and spinal cord
4
Q
This dopamine release circuit involves movement and sensory stimuli. It goes from the substantia nigra to the basal ganglia
A
Nigrostriatial
5
Q
What is acetylcholines role in the PNS?
A
Both parts of the parasympathetic subdivision, fist part of the sympathetic subdivision, and a neuromuscular junction (NMJ)
6
Q
What NT is norepinephrine made from?
A
Dopamine
7
Q
Three indolamines
A
Serotonin, melatonin, and histamine
8
Q
What behaviors are associated with norepinephrine?
A
Arousal (general state of wakefulness/excitability), vigilance, and mood
9
Q
How is dopamine inactivated/removed?
A
Enzymes Monoamine oxidase (MAO), catechol-O-methyl transferase (COMT), and aldehyde dehydrogenase, act in sequence to break it down
10
Q
Where is histamine released?
A
Tuberomamillary nucleus in hypothalamus
11
Q
These receptors bind nicotine
A
Nicotinic ACh receptors
12
Q
What is the main excitatory NT?
A
Glutamate
13
Q
How does an NMDA glutamate receptor work?
A
Glutamate binds to AMDA receptor first, causes the NMDA to twist and the Mg+ to leave, opening the channel and allowing calcium/sodium in for a wave of depolarization
14
Q
Where is glycine located?
A
Spinal interneurons, retina, and CNS (not usually acting independently)
15
Q
What are GPCRs and what do they indicate about receptors?
A
G protein coupled receptors. They are metabotropic
16
Q
What does noradrenaline mean?
A
Norepinephrine
17
Q
What would serotonin pills cause?
A
An overactive digestive system
18
Q
Where is acetylcholine released?
A
The basal forebrain and the cholinergic nuclei of the pons and midbrain
19
Q
What does adrenaline mean?
A
Epinephrine
20
Q
What dopamine receptors are excitatory?
A
D1 and D5 GPCRs (metabotropic)
21
Q
What causes aggression?
A
Low 5HT
22
Q
How is GABA made?
A
Made from glutamate by enzyme glutamic acid decarboxylase (GAD)
23
Q
What are the functions of glycine?
A
Inhibition, excitation at the NMDA glutamate receptor (co-activator), and sleep
24
Q
What do AMPA receptors do?
A
Open sodium channels. Ionotropic
25
What enzymes are associated with breaking down catecholamines?
Monoamine oxidase (MAO), catechol-O-methyl transferase (COMT), and aldehyde dehydrogenase
26
What clinical conditions/disorders are associated with norepinephrine?
Depression, anxiety, PTSD, ADHD
27
What is part of the catecholamines but isn't a NT?
L-Dopa
28
What receptors are associated with dopamine?
D1 and D5 are excitatory
| D2, D3, and D4 are inhibitory
29
Where is dopamine released from?
Substantia nigra (part of the midbrain) and sends to the basal ganglia. Ventral tegmentum projections to hippocampus, amygdala, and nucleus accumbens (mesolimbic). Ventral tegmentum projections to frontal lobe of the cortex (mesocortical)
30
What gas-transmitter easily crosses the blood-brain barrier?
Carbon monoxide (CO)
31
What is epinephrines role in the CNS?
Minimal. There are very few receptors in the brain.
32
What do NMDA receptors do and why are they special?
Opens channel for sodium and calcium. It is both voltage gated and ligand gated. Ionotropic
33
What are the iontropic receptors involved with glutamate?
AMPA - most common
Kainate
NMDA
34
What is substance P associated with?
Pain
35
How is glutamate removed?
Uptake into adjacent astrocytes. They change it to inactive and send it back to the axon terminal
36
How is GABA removed?
Uptake into adjacent astrocytes
37
What is cholecystokinin associated with?
Food/knowing when you've had enough fat
38
What is neuropeptide Y associated with?
Feeding/hunger/fullness
39
What receptors are involved with serotonin?
At least 15 different types and sub-types. Most are metabotropic and can be excitatory or inhibitory
40
Where is epinephrine released?
Adrenal glands near kidneys
41
What are oxytocin and vasopressin associated with?
Sex
42
What behaviors are associated with dopamine?
Movement control, reinforcement, planning, and reward
43
Three catecholamines
Dopamine, norepinephrine, epinephrine
44
How is histamine deactivated/removed?
Reuptake
45
What receptors do gasotransmitters interact with?
Intracellular receptors
46
How are catecholamines made? What must happen to make one and how are they related?
Each catecholamine is made from the one before it. They are in a series
47
These diffuse away from the point of release
NMs
48
What clinical conditions/disorders are associated with dopamine?
Parkinson's disease (not enough=movement problems), schizophrenia, drug abuse
49
What is histamines role in the PNS?
In stomach to stimulate production of HCl (inc HCl to digest) and in immune system to vasodilate in response to allergies (inc mucus bc of allergies)
50
What are the functions of glutamate?
Excitation and long-term memory
51
These are released at directed synapses with a clear target in mind. They act on neurons in immediate vicinity
NTs
52
Three categories of neurochemicals
Small molecules, neuropeptides, and gasotransmitters
53
These receptors are located at NMJ (neuromuscular junction), ANS (autonomic nervous system), and CNS (central nervous system) and are excitatory and postsynaptic
Nicotinic ACh receptors
54
What do Kainate receptors do?
Open sodium channels. Ionotropic
55
How do GABA-B receptors work?
Metabotropic less common of the two. Opens potassium channels allowing it to flow out
56
These are released at non-directed synapses (volume-transmission) and act on distant neurons
NMs and NHs
57
What does L-Dopa do?
It is needed to make the other catecholamines
58
What receptors are involved with histamines?
H1-H4 all metabotropic GPCRs
59
These receptors are metabotropic/GPCR and found in myocardial, smooth muscle (digestive tract), and CNS
Muscarinic ACh receptors
60
What is norepinephrines role in the PNS?
Sympathetic division (fight or flight), increase blood sugar levels, increase heart rate, narrow blood vessels to increase blood pressure
61
Where is adenosine located?
CNS, autonomic nervous system, in cells containing catecholamines
62
These receptors are blocked by the poison curare
Nicotinic ACh receptors
63
What NTs are the primary excitatory and inhibitory NTs?
Amino acid NTs
64
What do indolamines always end in?
-in
65
This dopamine release circuit involves cognition, memory, attention, emotional behavior, and learning. It goes from the ventral tegmentum projections to frontal lobe of cortex
Mesocortical
66
What receptors are associated with norepinephrine?
Alpha and beta receptors
67
What are the functions of adenosine?
Pain modulation (reduces it) and inhibition
68
What behaviors are associated with histamine?
Promotes wakefulness, movement, some roles in homeostasis
69
What does caffeine bind to and act similarly to?
It binds to adenosine receptors and acts similar to adenosine
70
These travel in blood supply
NHs
71
Two gasotransmitters
Nitric oxide, carbon monoxide
72
What are some gasotransmitters and what do they do?
Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). They transfer info from one cell to another and diffuse through membranes and interact with intracellular receptors
73
What clinical conditions/disorders are associated with serotonin?
Depression, OCD, anxiety, and many more
74
Three amino acids and how many others (involved in neurochemicals)?
Glutamate, GABA, glycine, and 5 others
75
What two NTs are needed to activate an NMDA receptor?
Glutamate and glycine
76
What does the suffix -ergic usually tell us?
It releases a NT
77
What is the abbreviation for serotonin
5HT
78
What are the behaviors of acetylcholine?
Autonomic functions like heart rate and breathing, movement through muscle contraction, and learning/memory because it helps us to pay attention
79
How many neuropeptides are there?
More than 100 and counting
80
This dopamine release circuit involves pleasure, reward, seeking behaviors, addiction, emotion, and perception. It goes from the ventral tegmentum projections to hippocampus, amygdala, and nucleus accumbens
Mesolimbic
81
What is serotonins role in the PNS?
Enteric (gut) motility (biggest source of 5HT) and it is involved in everything and responsible for almost nothing
82
What are the receptors involved with GABA?
GABA-A and GABA-B
83
These receptors bind muscarine and are blocked by the poison atropine
Muscarinic ACh receptors
84
What do NT, NM, and NH stand for?
Neurotransmitter, neuromodulator, and neurohormone
85
What specific disorders or clinical conditions is ACh associated with?
Alzheimers disease because the basal forebrain is one of the first places to deteriorate due to too little ACh, myasthenia gravis due to ACh not being able to bond, and schizophrenia because many are chain smokers and nicotine binds to ACh receptors
86
Why are NMDA receptors good at sending a strong signal?
They let in calcium which is very positive. It is a big deal for depolarization
87
How is histamine synthesized?
Made from the amino acid histidine
88
How is serotonin synthesized?
It is made from the amino acid tryptophan
89
What is a special trait of gasotransmitters?
They can transmit info from postsynaptic to presynaptic neurons. They can flow forward and back.
90
What is dopamines role in the PNS?
Modulation. Influences the activity of a lot of other NTs
91
How is norepinephrine synthesized?
Dopamine beta hydroxyolase converts dopamine into norepinephrine
92
What are the metabotropoic receptors involved with glutamate?
mGluRs
93
What are the functions of GABA?
Inhibition, mood (anxiety), and seizure threshold
94
What is the main inhibitory NT?
GABA
95
These receptors mediate both inhibition and excitation in target cells and are both presynaptic and postsynaptic
Muscarinic ACh receptors
96
Where is norepinephrine released?
Pons (locus coeruleus which projects widely to spinal cord and brain), medulla, hypothalamus, and postganglionic sympathetic synapses
97
What does adenosine usually co-occur with?
Catecholamines
98
How is ACh removed?
Breakdown by enzyme Acetylcholinesterase (ACHE)
99
How do GABA-A receptors work?
Ionotropic. Cl- ion channels allows Cl- to flow in. It has many binding sites including benzodiazepines, barbiturates, and ethanol (many binding sites other than GABA)
100
How is dopamine synthesized?
Dopa Decarboxylase converts L-Dopa into dopamine
101
How is glutamate synthesized?
Kreb's cycle
102
What clinical conditions/disorders are associated with histamines?
May be involved in immune system disorders or allergies or sleep disorders
103
How is serotonin deactivated/removed?
Reuptake by serotonin transporter and breakdown by monoamine oxidase (MAO)
104
What dopamine receptors are inhibitory?
D2, D3, and D4 GPCRs (metabotropic)
105
What is epinephrines role role in the PNS?
Increased blood sugar levels, increased heart rate, increased contractility (how hard the heart squeezes), relaxation of smooth muscle in the airways to improve breathing
106
What behaviors are associated with serotonin?
Mood, sleep/wake cycles, aggression, social rank, appetite
107
How is norepinephrine deactivated/removed?
Enzymes monoamine oxidase (MAO), catechol-O-methyl transferase (COMT), and aldehyde dehydrogenase acting in sequence to break down norepinephrine
108
How is ACh synthesized?
Choline from diet + Acetyl CoA enzyme choline acetyltransferase (ChAT)
109
Two categories of monoamines
Catecholamines and indolamines
110
What are endorphins associated with?
Runners high
111
Seven neuropeptides and how many others?
Endorphins, substance P, cholecystokinin, insulin, vasopressin, oxytocin, neuropeptide Y, and more than 40 others
