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Flashcards in Neurological Disorders Deck (111)
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1

Gene that makes people more vulnerable to AD and CTE

APOE e4 variant

2

Outside the cell protein build up. AD

Amyloid B plaques

3

Inside brain

Intracerebral

4

When immune system overreacts to virus in other parts of body such as herpes, chickenpox, measles, or polio. Brain gets hit in crossfire, more common

Secondary encephalitis

5

Aneurysms (bursting of a blood vessel)

Cerebral hemorrhage

6

A neurodegenerative condition associated with aging that results in dementia

Alzheimers

7

Clear edges. Easier to remove

Non-gliomas (meningioma)

8

Always fatal, caused by prions, holes in the brain that shouldn't be there

CJD

9

80% of infected show no symptoms

West nile virus

10

Ischemia and transient ischemic attacks, infarct/penumbra, thrombosis vs embolism

Sudden blockage of a blood vessel

11

Higher risk for migraines in men or women?

Women

12

2 things that are sign of AD and contribute strongly to it

Amyloid B plaques and neurofibrillary tau tangles

13

What is Kuru?

Creutzfeldt jakob disease in Papua New Guinea tribe

14

Virtual reality therapy

Patients participate without expensive staff

15

Spread through mosquitos

West nile virus

16

Demyelination of axons that starts slow and gets more and more and affects white matter in different locations

Multiple sclerosis

17

What causes TSEs?

Prions

18

What limits chemo therapy for brain tumors?

The blood brain barrier

19

Blockage of CNS vasculature leads to this, or low oxygen levels

Ischemia

20

What causes physical damage to the brain

Open head injuries: penetration of the skull

21

Can withstand sterilization, long incubation period, no inflammation

Prion

22

Inflammation of the brain caused by viral infection

Encephalitis

23

Symptoms of fever, headache, body aches, nausea, vomiting

West nile virus

24

When virus directly invades CNS (West Nile virus)

Primary encepahlitis

25

AD treatments

Experimental antibodies targeting amyloid B clear plaques, increasing seafood/omega 3 fatty acid intake, acetylcholinesterase inhibitors, antipsychotics (dopamine antagonists)

26

Repetitive unprovoked seizures

Epilepsy

27

How can the APOE e4 allele be inherited?

As a dominant trait due to mutations in either the APP, PSEN1, or PSEN2 genes

28

3 stages of CJD (kuru)

1. ambulant followed by laughing
2. sedentary (sitting/laying)
3. terminal (organ systems shut down)

29

In middle of meninges

Subarachnoid

30

Inside the cell protein clumps. Causes the cell to lose function and die. AD

Neurofibrillary tau tangles