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Flashcards in Pharmacology for Exam 2 Deck (63)
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1

What do non-competitive antagonists do?

They bind to a site on the receptor that keeps the channel closed but isn't the same site as the NT. When the NT binds to its site on the receptor, it does not activate and the channel stays closed

2

What do MDMA and SSRI's (Prozac, etc.) do? Agonist or antagonist?

Inhibit serotonin reuptake. Agonist

3

What does additional L-dopa do? Agonist or antagonist?

Increases dopamine production. Agonist

4

What do cocaine, amphetamines, and methylphenidate (Ritalin) do? Agonist or antagonist?

Inhibit dopamine reuptake. Agonist.

5

What two types of antagonists are there?

Competitive and non-competitive

6

What do cocaine, amphetamine, and Ritalin do?

Inhibit dopamine reuptake

7

What do SSRIs (Prozac) do?

Inhibit serotonin reuptake

8

What do migraine medications do? Agonist or antagonist?

Stimulate serotonin receptors. Agonist

9

What is an antagonist?

A drug that blocks or decreases the effect of a NT

10

What do MAO inhibitors do? Agonist or antagonist?

Interfere with the breakdown of monoamines including serotonin. Agonist

11

LOOK AT THE TWO CHARTS AT END OF NOTES

LOOK AT THE TWO CHARTS AT END OF NOTES

12

What do organophostaphates do?

They interfere with the enzyme AChE. Involved in enzyme degradation in the synapse

13

When the ligand fits perfectly with the receptor

High affinity

14

Any substance that alters the body or its functions

Drug

15

What does an increase in tryptophan from food do? Agonist or antagonist?

Increases serotonin production. Agonist

16

What do agonists do to receptors?

They activate receptors

17

Strength of association between ligand and receptor. How well it binds to the receptor

Affinity

18

What does apomorphine do? Agonist or antagonist?

Stimulates dopamine receptors. Agonist

19

Therapeutic index (wide vs narrow)

Wide is safe and narrow is risky. The line where the dose changes from mostly positive to mostly negative effects

20

What does nicotine do? Is it an agonist or antagonist?

Stimulates ACh receptors. Agonist

21

Amount of drug required to produce a certain response. Indicates power

Potency

22

Where do drugs act presynaptically?

NT production, NT storage, and NT release

23

What do drugs that treat the negative symptoms of schizophrenia do? Agonist or antagonist?

Block serotonin receptors. Antagonist

24

What may apomorphine be able to help treat?

Parkinson's disease. Not currently approved for treatment, however.

25

Drugs that block the synaptic activity by occupying a binding site different from the NT on a receptor

Competitive or non-competitive antagonists

26

Property of a drug that determines its ability to produce its biological effect. How much response we are getting

Efficacy

27

Example of a drug affecting NT storage

Reserpine (used to treat mild to moderate hypertension) affecting storage of norepinephrine. Presynaptic

28

What is ED50?

The effective dose where you get 50% of the desired response

29

What do competitive antagonists do?

They bind to the site where a NT would bind and block it from binding with the receptor. The channel stays closed

30

How do drugs affect NT storage?

They interfere with the storage of a NT in vesicles within a neuron. Presynaptic