Flashcards in Pharmacology for Exam 2 Deck (63)
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1
What do non-competitive antagonists do?
They bind to a site on the receptor that keeps the channel closed but isn't the same site as the NT. When the NT binds to its site on the receptor, it does not activate and the channel stays closed
2
What do MDMA and SSRI's (Prozac, etc.) do? Agonist or antagonist?
Inhibit serotonin reuptake. Agonist
3
What does additional L-dopa do? Agonist or antagonist?
Increases dopamine production. Agonist
4
What do cocaine, amphetamines, and methylphenidate (Ritalin) do? Agonist or antagonist?
Inhibit dopamine reuptake. Agonist.
5
What two types of antagonists are there?
Competitive and non-competitive
6
What do cocaine, amphetamine, and Ritalin do?
Inhibit dopamine reuptake
7
What do SSRIs (Prozac) do?
Inhibit serotonin reuptake
8
What do migraine medications do? Agonist or antagonist?
Stimulate serotonin receptors. Agonist
9
What is an antagonist?
A drug that blocks or decreases the effect of a NT
10
What do MAO inhibitors do? Agonist or antagonist?
Interfere with the breakdown of monoamines including serotonin. Agonist
11
LOOK AT THE TWO CHARTS AT END OF NOTES
LOOK AT THE TWO CHARTS AT END OF NOTES
12
What do organophostaphates do?
They interfere with the enzyme AChE. Involved in enzyme degradation in the synapse
13
When the ligand fits perfectly with the receptor
High affinity
14
Any substance that alters the body or its functions
Drug
15
What does an increase in tryptophan from food do? Agonist or antagonist?
Increases serotonin production. Agonist
16
What do agonists do to receptors?
They activate receptors
17
Strength of association between ligand and receptor. How well it binds to the receptor
Affinity
18
What does apomorphine do? Agonist or antagonist?
Stimulates dopamine receptors. Agonist
19
Therapeutic index (wide vs narrow)
Wide is safe and narrow is risky. The line where the dose changes from mostly positive to mostly negative effects
20
What does nicotine do? Is it an agonist or antagonist?
Stimulates ACh receptors. Agonist
21
Amount of drug required to produce a certain response. Indicates power
Potency
22
Where do drugs act presynaptically?
NT production, NT storage, and NT release
23
What do drugs that treat the negative symptoms of schizophrenia do? Agonist or antagonist?
Block serotonin receptors. Antagonist
24
What may apomorphine be able to help treat?
Parkinson's disease. Not currently approved for treatment, however.
25
Drugs that block the synaptic activity by occupying a binding site different from the NT on a receptor
Competitive or non-competitive antagonists
26
Property of a drug that determines its ability to produce its biological effect. How much response we are getting
Efficacy
27
Example of a drug affecting NT storage
Reserpine (used to treat mild to moderate hypertension) affecting storage of norepinephrine. Presynaptic
28
What is ED50?
The effective dose where you get 50% of the desired response
29
What do competitive antagonists do?
They bind to the site where a NT would bind and block it from binding with the receptor. The channel stays closed
30
