Research Methods in Behavioral Neuroscience Flashcards Preview

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Flashcards in Research Methods in Behavioral Neuroscience Deck (59)
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1

Microdialysis

Measure neurotransmitter output from local brain region

2

Histology

Microanatomy of cells

3

Sort of stains opposite nissil stains

myelin stain

4

Random which cells take the stain. Single cell. Complex structure

Golgi stain

5

What does the speed tell us when looking at research

Temporal resolution. Slow vs fast. The timing

6

Molecules tagged with radioactive isotope and injected into blood. Positrons are emitted, collide with electrons, create photons that are detectable

Positron Emission Tomography (PET)

7

Individual neurons express different colors

brainbow

8

Infusion

Put chemicals directly in to local brain region. Keep it from being widespread. Only affects one area.

9

Great still image quality, no radiation. Long scan time, expensive, claustrophobic

Magnetic Resonance Imaging (MRI)

10

Low vs High invasiveness

Does it require surgery?

11

Early method used to inaccurately link bumps to traits. Led to localizations

Phrenology

12

Shows structural connections

brainbow

13

Improved spatial resolution over EEG, fast temp. resolution, non-invasive. Very large, expensive, requires helium for SQUID sensor.

Magnetoencephalogram (MEG)

14

Aligns water molecules, adjusts the molecules, then takes an image

MRI

15

Criticized as "dead fish" and modern phrenology

fMRI

16

Fine wire/glass electrodes implanted into brain. Answers when action potentials correlate with behavior. Fast temporal resolution with small spatial resolution

Intracellular: Microelectrode single unit or multi unit

17

Used in gene editing: Cre-Lox recombination. Merging genetics and neuroscience

brainbow

18

Records sum total of extracellular post-synaptic potentials (not action potentials)

Electroencephalogram (EEG)

19

Piercing the skull

craniotomy

20

Nissil Stains

Cell bodies/nuclei, layers

21

Identifies neural pathways and connections

myelin stain

22

Cannulation

Insert a specialized probe

23

What does the scale tell us when looking at research

Spatial resolution. Small vs large. The zoom

24

Accessible, good for diagnosing, less claustrophobic, quick scan time. Not great quality, not often used in research, radiation exposure

CT scan

25

Microcrystalization of silver chromate

Golgi stain

26

Recorded with micro electrode arrays implanted in brain. Detects oscillatory (sinusoidal) patterns. Like sections in a stadium. When regions are synchronized in electrical communication

Extracellular: Local field potentials (LFP)

27

Light coloring shows cell bodies, dendrites

myelin stain

28

High temp. resolution, safe, portable, affordable. Low spatial resolution, can't go beyond a few mm deep, signal noise

Electroencephalogram (EEG)

29

Golgi Silver Stain

Structural. Random single cells, structural features.

30

How do you pick the right tool

depends on the population you study