Prototype Drug Unit 3 & 4- Latanoprost

Question 1

Therapeutic classification

Answer 1

Drug for glaucoma

Question 2

Pharmacologic classification

Answer 2

prostaglandin analog

Question 3

Therapeutic effects and uses

Answer 3

reduce IOP by increasing the outflow of aqueous humor for patients with open-angle glaucoma and ocular HTN. It is recommended dose is one drop in the affected eyes in the evening. It is used to treat open-angle glaucoma

Question 4

Mechanism of action

Answer 4

Reduces elevated IOP in patients with open-angle glaucoma.

Question 5

Route

Answer 5

Ophthalmic solution

Question 6

Absorption

Answer 6

Through the cornea

Question 7

Distribution

Answer 7

Enters systemic distribution in small amounts

Question 8

Metabolism

Answer 8

Metabolized in the aqueous humor to its active form

Question 9

Excretion

Answer 9

Renal

Question 10

Adverse effects

Answer 10

conjunctival edema, tearing, dryness, burning, pain, irritation, itching, sensation of a foreign body in the eye, photophobia, or visual disturbances.

Question 11

Contraindications/Precautions

Answer 11

Contraindications: hypersensitivity, pregnancy lactation, intraocular infection, or conjunctivitis

Question 12

Drug interactions

Answer 12

If used with other eyedrops that contain thimerosal, precipitation may occur

Question 13

Pregnancy category

Answer 13

C