Prototype Drug Unit 5 & 7- Ibuprofen

Question 1

Therapeutic

Answer 1

Analgesic, anti-inflammatory drug, antipyretic

Question 2

Pharmacologic classification

Answer 2

NSAID

Question 3

Therapeutic uses and effects

Answer 3

Used to treat inflammation and fevers and pain. Not used for cardiac issues

Question 4

Mechanism of action

Answer 4

Inhibits inflammatory cell chemotaxis, decreases the release of superoxide radicals, and increases the scavenging of these products at the inflammatory site.

Question 5

Adverse effects

Answer 5

GI related issues (bleeding, anorexia, heartburn, nausea, vomiting, and constipation or diarrhea) (kinda the same as aspirin).
CNS effects (dizziness, headache, drowsiness, and lightheadedness)
Other (hypotension, heart failure, peripheral edema)

Question 6

Black box warning

Answer 6

May increase the risk of serious and potentially fatal cardiovascular thrombin events, myocardial infarction, and stroke

Question 7

Contraindications/ precautions

Answer 7

Contraindications: allergy to aspirin or other NSAIDs, PUD, GERD, bleeding abnormalities, pain related to CABG(coronary artery bypass graft)

Question 8

Drug interactions

Answer 8

Oral anticoagulants and anti platelet drugs increase risk of bleeding. Increased GI probs if taken with other NSAIDs, alcohol, corticosteroids.

Question 9

Herbal/food interactions

Answer 9

Feverfew, garlic, ginger, and gingko can increase risk of bleeding

Question 10

Treatment of overdose

Answer 10

Charcoal and nasogastric suction