Prototype Drug Unit 3 & 4- Medroxyprogesterone

Question 1

Therapeutic classification

Answer 1

Hormone, drug for dysfunctional uterine bleeding

Question 2

Pharmacologic classification

Answer 2

progestin

Question 3

Therapeutic effects and uses

Answer 3

It antagonizes the effects of estrogen on the uterus, thus restoring normal hormonal balance. Prevents ovulation, and causes a thick cervical mucus that is resistant to the passage of sperm.

Question 4

Mechanism of action

Answer 4

The drug inhibits GnRH, thus preventing the LH surge and ovulation

Question 5

Route

Answer 5

PO, IM, subcutaneous, IV

Question 6

Absorption

Answer 6

Readily absorbed from the GI tract or IM

Question 7

Distribution

Answer 7

Crosses the placenta; secreted in breast milk; 90% bound to protein

Question 8

Metabolism

Answer 8

Hepatic

Question 9

Excretion

Answer 9

Feces

Question 10

Adverse effects

Answer 10

Breast tenderness and breakthrough bleeding and other menstrual irregularities. Weight gain, depresison, hypertension (HTN), nausea, vomiting, fluid retention, and vaginal candidiasis

Question 11

Black Box Warning

Answer 11

Progestins with estrogens may increase the risk of stroke, DVT, myocardial infarction, pulmonary emboli, and invasive breast cancer

Question 12

Contraindications/Precaution

Answer 12

Contraindications: history of thromboembolic disorders, pregnancy, lactation, preexisting breast, uterine, or vaginal cancer.

Precautions: hepatic impairment, psychic depression

Question 13

Drug interactions

Answer 13

Serum levels are decreased by aminoglutethimide, barbituates, primidone, rifampin, rifabutin, topiramate

Question 14

Herbal/ food interactions

Answer 14

St. John’s wort may cause intermenstrual bleeding and loss of efficacy

Question 15

Pregnancy category

Answer 15

X