Prototype Drug Unit 6- Gemfibrozil

Question 1

Therapeutic classification

Answer 1

Antihyperlipidemic

Question 2

Pharmacologic classification

Answer 2

Fabric acid drug (fibrate)

Question 3

Therapeutic effects and uses

Answer 3

Lowers triglycerides and LDL cholesterol. Used for patients who have hypertriglyceridemia and VLDL.

Question 4

Mechanism of action

Answer 4

Inhibits the breakdown of stored fat, or lipolysis, in adipose tissue. By sopping the uptake of free fatty acids by the liver, hepatic reproduction of triglycerides is decreased

Question 5

Adverse effects

Answer 5

GI related (abdominal cramping, diarrhea, nausea, and dyspepsia)
Nervous system (headaches, dizziness, peripheral neuropathy, and diminished libido)

Question 6

Contraindications

Answer 6

Don’t give to people with liver or gallbladder probs. Be careful with people who have kidney probs.

Question 7

Drug interactions

Answer 7

Combined with statins= Myositis and rhabdomyolysis
PO anticoagulants= risk of bleeding because fibrates displace warfarin from its plasma binding proteins
Anti diabetic drugs= enhance low blood sugar effects

Question 8

Important info

Answer 8

Take with meals in order to decrease GI problems